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首页> 外文期刊>Comparative Medicine >Infectious Diseases in Wild Mice (Mus musculus) Collected on and around the University of Pennsylvania (Philadelphia) Campus.
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Infectious Diseases in Wild Mice (Mus musculus) Collected on and around the University of Pennsylvania (Philadelphia) Campus.

机译：在宾夕法尼亚大学（费城）校园内外收集野生小鼠的传染性疾病。

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Laboratory mice serve as important models in biomedical research. Monitoring these animals for infections and infestations and excluding causative agents requires extensive resources. Despite advancements in detection and exclusion over the last several years, these activities remain challenging for many institutions. The infections and infestations present in laboratory mouse colonies are well documented, but their mode of introduction is not always known. One possibility is that wild rodents living near vivaria somehow transmit infections to and between the colonies. This study was undertaken to determine what infectious agents the wild mice on the University of Pennsylvania (Philadelphia) campus were carrying. Wild mice were trapped and evaluated for parasites, viruses, and selected bacteria by using histopathology, serology, and PCR-based assays. Results were compared with known infectious agents historically circulating in the vivaria housing mice on campus and were generally different. Although the ectoparasitic burdens found on the 2 populations were similar, the wild mice had a much lower incidence of endoparasites (most notably pinworms). The seroprevalence of some viral infections was also different, with a low prevalence of mouse hepatitis virus among wild mice. Wild mice had a high prevalence of murine cytomegalovirus, an agent now thought to be confined to wild mouse populations. Helicobacter DNA was amplified from more than 90% of the wild mice (59% positive for H. hepaticus). Given the results of this study, we conclude that wild mice likely are not a source of infection for many of the agents that are detected in laboratory mouse colonies at the University of Pennsylvania.
机译：实验小鼠是生物医学研究中的重要模型。监测这些动物的感染和侵扰并排除致病因素需要大量资源。尽管最近几年在检测和排除方面取得了进步，但对于许多机构而言，这些活动仍然充满挑战。实验室小鼠菌落中存在的感染和侵扰已得到充分记录，但引入方式并不总是已知的。一种可能性是生活在vivaria附近的野生啮齿动物以某种方式将感染传播到菌落之间。进行这项研究是为了确定宾夕法尼亚大学（费城）校园内的野生小鼠携带哪些传染原。捕获野生小鼠并通过组织病理学，血清学和基于PCR的检测方法评估其寄生虫，病毒和选定的细菌。将结果与历史上曾在校园内的vivaria饲养小鼠中循环传播的已知传染原进行了比较，并且通常有所不同。尽管在这两个种群上发现的体外寄生虫负担相似，但野生小鼠的体内寄生虫（尤其是pin虫）的发生率要低得多。一些病毒感染的血清流行率也不同，在野生小鼠中小鼠肝炎病毒的流行率较低。野生小鼠的鼠巨细胞病毒感染率很高，现在认为这种药物仅限于野生小鼠种群。从超过90％的野生小鼠中扩增出了Helicobacter DNA（肝炎支原体阳性率为59％）。根据这项研究的结果，我们得出结论，在宾夕法尼亚大学的实验室小鼠群落中检测到的许多病原体，可能不是野生小鼠的感染源。

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