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首页> 外文期刊>Comparative Medicine >Complications of Elastase-Induced Arterial Saccular Aneurysm in Rabbits: Case Reports and Literature Review
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Complications of Elastase-Induced Arterial Saccular Aneurysm in Rabbits: Case Reports and Literature Review

机译：弹性蛋白酶诱导的兔动脉囊性动脉瘤的并发症：病例报告和文献复习

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Endoluminal infusion and incubation of elastase with or without collagenase into the rabbit common carotid artery is an established model of arterial saccular aneurysm. The model mimics naturally occurring human cerebral aneurysms in many ways, including histologic and morphologic characteristics, hemodynamic pressures, and shear stresses. However, complications have been associated with the model. Here, we report 2 complications: 1) the first known case of iatrogenic laryngeal hemiplegia in a rabbit; and 2) histopathologically confirmed iatrogenic hippocampal and cerebellar infarcts (stroke). Finally, we present and review data from current literature on the morbidity and mortality associated with this model.
机译：腔内输注以及将弹性蛋白酶与胶原酶一起或不与胶原酶一起孵育到兔颈总动脉中是动脉囊状动脉瘤的既定模型。该模型以多种方式模拟自然发生的人脑动脉瘤，包括组织学和形态学特征，血流动力学压力和切应力。但是，复杂性已经与模型相关联。在这里，我们报告2种并发症：1）兔中首例医源性喉偏瘫; 2）在组织病理学上证实的医源性海马和小脑梗塞（中风）。最后，我们提出并回顾了当前文献中与该模型相关的发病率和死亡率的数据。

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