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首页> 外文期刊>Comparative Medicine >Subsets of T cells in healthy rhesus macaques (Macaca mulatta) infected with simian T-lymphotropic virus type 1
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Subsets of T cells in healthy rhesus macaques (Macaca mulatta) infected with simian T-lymphotropic virus type 1

机译：猿猴T淋巴病毒1型感染的健康恒河猴（猕猴）中T细胞亚群

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摘要

Simian T-lymphotropic virus type 1 (STLV-1) is a C-type retrovirus of nonhuman primates that is genetically and antigenically related to human T-lymphotropic virus type 1 (HTLV-1). Infection with STLV-1 has been reported in many species of Old World monkeys and apes, including rhesus macaques (Macaca mulatta). Similar to HTLV infection in humans, STLV infection has been associated with T-cell lymphoproliferative disease or lymphoma in a small proportion of infected animals, predominantly African species. There are conflicting reports of T-cell subset alterations in healthy HTLV-1 carriers. To the authors' knowledge, analysis of T-cell subsets in healthy STLV-1 carrier rhesus macaques has not been reported. Subsets of T cells in peripheral blood from healthy, STLV-1-seropositive rhesus macaques (n = 17) and seronegative controls matched for age and sex (n = 17) were determined by use of fluorescence-activated cell sorter analysis. Parameters measured included CD3, CD4, CD8, CD25, CD28, CD38, and HILA-DR cell sets. Significant differences in T-cell subsets or hematologic parameters were not observed between healthy STLV-seropositive and seronegative groups.
机译：猿猴T淋巴病毒1型（STLV-1）是非人类灵长类动物的C型逆转录病毒，与人类T淋巴病毒1型（HTLV-1）遗传和抗原相关。据报道，在旧世界的许多猴子和猿猴中都感染了STLV-1，其中包括猕猴（Macaca mulatta）。与人类的HTLV感染相似，STLV感染与一小部分受感染动物（主要是非洲物种）的T细胞淋巴增生性疾病或淋巴瘤相关。健康HTLV-1携带者中T细胞亚群改变的报道存在矛盾。据作者所知，尚未报道健康的STLV-1携带型恒河猴的T细胞亚群的分析。通过使用荧光激活细胞分选仪分析，确定健康，STLV-1血清阳性恒河猴（n = 17）和血清阴性对照（年龄和性别相匹配）的外周血T细胞亚群。测量的参数包括CD3，CD4，CD8，CD25，CD28，CD38和HILA-DR细胞组。在健康的STLV血清阳性和血清阴性组之间未观察到T细胞亚群或血液学参数的显着差异。

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