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Persistent mammary hyperplasia in FVB/N mice

机译：FVB / N小鼠持续性乳腺增生

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The inbred FVB/N mouse strain is widely used for creating transgenic mice. Over the past decade, persistent mammary hyperplasia has been detected in many multiparous FVB/N female mice sent to the University of California, Davis (UCD) Mutant Mouse Pathology Laboratory (MMPL) by a number of different laboratories. However, the experimental details concerning most specimens were not always available. To confirm these empiric findings, experiments were carried out to evaluate the mammary glands of FVB/N mice under controlled conditions. Persistent mammary hyperplasia that related to parity was found. Weeks after their first to fourth pregnancy, 10 FVB/N female mice from the Lawrence Berkeley National Laboratory (LBNL) colony were studied and the mammary glands were evaluated. The percentage of fat pad filled was estimated, using image analysis. Serum samples and the pituitary gland from other FVB/N mice from the LBNL were assayed for prolactin concentration. Multiparous FVB/N females consistently had persistent mammary hyperplasia. Four of seven females in the LBNL colony had hyperplasia after three pregnancies. A few foci of squamous nodules and sporadic carcinomas also were observed. Thus, some FVB/N females may have persistent mammary hyperplasia after three pregnancies without detectable pituitary abnormalities. Mammary carcinomas also may develop sporadically. These background phenotypes must be considered when interpreting the effect of genetic manipulation in FVB/N mice.
机译：自交FVB / N小鼠品系被广泛用于创建转基因小鼠。在过去的十年中，已通过许多不同的实验室在许多送往加利福尼亚大学戴维斯分校（UCD）突变小鼠病理学实验室（MMPL）的FVB / N雌性小鼠中检测到持续性乳腺增生。但是，有关大多数标本的实验细节并非总是可用。为了证实这些经验性发现，进行了实验以评估FVB / N小鼠在受控条件下的乳腺。发现与胎次有关的持续性乳腺增生。在第一胎至第四胎怀孕数周后，研究了来自劳伦斯伯克利国家实验室（LBNL）菌落的10只FVB / N雌性小鼠，并评估了乳腺。使用图像分析估计填充的脂肪垫的百分比。分析了来自LBNL的其他FVB / N小鼠的血清样品和垂体的催乳素浓度。多胎FVB / N女性持续存在持续的乳腺增生。 LBNL菌落中的七名女性中有四名在三胎后增生。还观察到一些鳞状结节和散发性癌灶。因此，某些FVB / N女性在三胎妊娠后可能存在持续性乳腺增生，而未发现垂体异常。乳癌也可能偶尔发生。在解释FVB / N小鼠中基因操作的影响时，必须考虑这些背景表型。

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