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首页> 外文期刊>Comparative Medicine >Four-Point Bending as a Method for Quantitatively Evaluating Spinal Arthrodesis in a Rat Model
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Four-Point Bending as a Method for Quantitatively Evaluating Spinal Arthrodesis in a Rat Model

机译：四点弯曲作为一种定量评估大鼠模型中的脊柱关节固定术的方法

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摘要

The most common method of evaluating the success (or failure) of rat spinal fusion procedures is manual palpation testing. Whereas manual palpation provides only a subjective binary answer (fused or not fused) regarding the success of a fusion surgery, mechanical testing can provide more quantitative data by assessing variations in strength among treatment groups. We here describe a mechanical testing method to quantitatively assess single-level spinal fusion in a rat model, to improve on the binary and subjective nature of manual palpation as an end point for fusion-related studies. We tested explanted lumbar segments from Sprague Dawley rat spines after single-level posterolateral fusion procedures at L4-L5. Segments were classified as 'not fused,' 'restricted motion,' or 'fused' by using manual palpation testing. After thorough dissection and potting of the spine, 4-point bending in flexion then was applied to the L4-L5 motion segment, and stiffness was measured as the slope of the moment displacement curve. Results demonstrated statistically significant differences in stiffness among all groups, which were consistent with preliminary grading according to manual palpation. In addition, the 4-point bending results provided quantitative information regarding the quality of the bony union formed and therefore enabled the comparison of fused specimens. Our results demonstrate that 4-point bending is a simple, reliable, and effective way to describe and compare results among rat spines after fusion surgery.
机译：评估大鼠脊柱融合手术成功与否的最常见方法是手动触诊测试。手动触诊仅提供关于融合手术成功的主观二元答案（融合或未融合），而机械测试可通过评估治疗组之间的强度变化来提供更多定量数据。我们在这里描述了一种机械测试方法，以定量评估大鼠模型中的单级脊柱融合，以改善手动触诊的二元和主观性质，作为融合相关研究的终点。我们在L4-L5进行单级后外侧融合手术后，测试了Sprague Dawley大鼠脊柱的离体腰段。使用手动触诊测试将节段分为“未融合”，“受限运动”或“融合”。在对脊柱进行彻底解剖和包扎之后，将四点屈曲弯曲施加到L4-L5运动段，并测量刚度作为力矩位移曲线的斜率。结果表明，所有组之间的刚度在统计学上均存在显着差异，这与根据手动触诊进行的初步分级一致。此外，四点弯曲结果提供了有关所形成的骨结合质量的定量信息，因此可以比较融合的样本。我们的结果表明，四点弯曲是一种简单，可靠且有效的方式，用于描述和比较融合手术后大鼠棘突之间的结果。

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