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首页> 外文期刊>Comparative Medicine >Development of a Cerebrospinal Fluid Lateral Reservoir Model in Rhesus Monkeys (Macaca mulatta)
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Development of a Cerebrospinal Fluid Lateral Reservoir Model in Rhesus Monkeys (Macaca mulatta)

机译：恒河猴（Macaca mulatta）脑脊液侧向储层模型的建立。

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Rapid, serial, and humane collection of cerebrospinal fluid (CSF) in nonhuman primates (NHP) is an essential element of numerous research studies and is currently accomplished via two different models. The CSF reservoir model (FR) combines a catheter in the 4th ventricle with a flexible silastic reservoir to permit circulating CSF flow. The CSF lateral port model (LP) consists of a lateral ventricular catheter and an IV port that provides static access to CSF and volume restrictions on sample collection. The FR model is associated with an intensive, prolonged recovery and frequent postsurgical hydrocephalus and nonpatency, whereas the LP model is associated with an easier recovery. To maximize the advantages of both systems, we developed the CSF lateral reservoir model (LR), which combines the beneficial features of the 2 previous models but avoids their limitations by using a reservoir for circulating CSF flow combined with catheter placement in the lateral ventricle. Nine adult male rhesus monkeys were utilized in this study. Pre-surgical MRI was performed to determine the coordinates of the lateral ventricle and location of choroid plexus (CP). The coordinates were determined to avoid the CP and major blood vessels. The predetermined coordinates were 100% accurate, according to MRI validation. The LR system functioned successfully in 67% of cases for 221 d, and 44% remain functional at 426 to 510 d postoperatively. Compared with established models, our LR model markedly reduced postoperative complications and recovery time. Development of the LR model was successful in rhesus macaques and is a useful alternative to the FR and LP methods of CSF collection from nonhuman primates.
机译：非人类灵长类动物（NHP）中快速，连续和人道地收集脑脊液（CSF）是众多研究研究的重要要素，目前已通过两种不同的模型完成。 CSF储库模型（FR）将第四脑室中的导管与柔性硅橡胶储库结合使用，以允许CSF循环流动。 CSF侧向端口模型（LP）由侧向心室导管和IV端口组成，该端口可提供静态通向CSF的通道以及样品采集的体积限制。 FR模型与密集，延长的恢复以及频繁的术后脑积水和不通畅相关，而LP模型与更容易恢复相关。为了最大化两个系统的优势，我们开发了CSF侧储库模型（LR），该模型结合了先前2种模型的有益功能，但通过使用储库来循环CSF流动并在侧脑室中放置导管，避免了它们的局限性。在该研究中使用了九只成年雄性恒河猴。进行术前MRI检查以确定侧脑室的坐标和脉络丛（CP）的位置。确定坐标以避免CP和主要血管。根据MRI验证，预定坐标为100％准确。 LR系统在67％的病例中成功运行了221 d，并且在术后426至510 d时仍保持了44％的功能。与已建立的模型相比，我们的LR模型显着减少了术后并发症和恢复时间。 LR模型的开发在恒河猴中获得成功，并且是从非人类灵长类动物收集CSF的FR和LP方法的有用替代方法。

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