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Biospecimen Reporting for Improved Study Quality

机译：生物标本报告可提高研究质量

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摘要

Human biospecimens are subject to a number of different collection, processing, and storage factors that can significantly alter their molecular composition and consistency. These biospecimen preanalytical factors, in turn, influence experimental outcomes and the ability to reproduce scientific results. Currently, the extent and type of information specific to the biospecimen preanalytical conditions reported in scientific publications and regulatory submissions varies widely. To improve the quality of research utilizing human tissues, it is critical that information regarding the handling of biospecimens be reported in a thorough, accurate, and standardized manner. The Biospecimen Reporting for Improved Study Quality recommendations outlined herein are intended to apply to any study in which human biospecimens are used. The purpose of reporting these details is to supply others, from researchers to regulators, with more consistent and standardized information to better evaluate, interpret, compare, and reproduce the experimental results. The Biospecimen Reporting for Improved Study Quality guidelines are proposed as an important and timely resource tool to strengthen communication and publications around biospecimen-related research and help reassure patient contributors and the advocacy community that the contributions are valued and respected.
机译：人类生物标本受到许多不同的收集，加工和存储因素的影响，这些因素会显着改变其分子组成和一致性。这些生物样本的分析前因素进而影响实验结果和再现科学结果的能力。当前，科学出版物和法规文件中报告的针对生物样本分析前条件的信息的范围和类型差异很大。为了提高利用人体组织的研究质量，至关重要的是，以彻底，准确和标准化的方式报告有关生物标本处理的信息。本文概述的《提高生物质量的生物样品报告》建议适用于使用人类生物样品的任何研究。报告这些详细信息的目的是为其他人员（从研究人员到监管机构）提供更一致和标准化的信息，以更好地评估，解释，比较和再现实验结果。提出《生物样品报告以提高研究质量》指南是一种重要且及时的资源工具，旨在加强与生物样品相关研究的交流和出版物，并帮助向患者贡献者和倡导社区保证其贡献得到重视和尊重。

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