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Quality Assurance in Cancer Biobanking

机译：癌症生物库中的质量保证

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摘要

Biobanking is recognized as a critical area requiring development if progress is to be made in identifying clinically useful markers of disease and disease progression, discovering new drug targets, and understanding the mechanisms of disease in cancer. Researchers continue to report that they are unable to obtain sufficient high-quality, well-annotated samples of diseased and control tissue, blood, and other biological materials. At the same time, funders of research, and especially funders of biobanks, are looking to obtain the best value from their investments in sample and data collection. There is a need to increase the availability to researchers of large numbers of high-quality, well-annotated samples of diseased and control tissue, blood, and other biological materials and, in this way, accelerate cancer research. To do this, samples need to be collected, processed, and stored in standardized ways that give assurance to researchers that they are fit for purpose. Quality assurance is an essential part of good science and this article describes how quality assurance is applied in cancer biobanking and discusses the need for internationally acceptable standards.
机译：如果要在确定疾病和疾病进展的临床有用标记，发现新药物靶标以及了解癌症疾病机理方面取得进展，则生物库被认为是需要发展的关键领域。研究人员继续报告说，他们无法获得足够的高质量，高注释率的患病和对照组织，血液和其他生物材料的样本。同时，研究的资助者，尤其是生物库的资助者，正在寻求从其在样本和数据收集方面的投资中获得最大的价值。有必要增加对研究人员的可用性，使他们获得大量病态和对照组织，血液和其他生物材料的高质量，批注充分的样品，并以此方式加快癌症研究的进程。为此，需要以标准化的方式收集，处理和存储样本，以向研究人员保证样本适合目的。质量保证是良好科学的重要组成部分，本文介绍了如何在癌症生物库中应用质量保证，并讨论了对国际认可标准的需求。

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