首页> 外文期刊>Biopreservation and biobanking >Models of Biobanking and Tissue Preservation: RNA Quality in Archival Samples in Pathology Laboratories and ‘‘In Vivo Biobanking’’ by Tumor Xenografts in Nude Mice—Two Models of Quality Assurance in Pathology
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Models of Biobanking and Tissue Preservation: RNA Quality in Archival Samples in Pathology Laboratories and ‘‘In Vivo Biobanking’’ by Tumor Xenografts in Nude Mice—Two Models of Quality Assurance in Pathology

机译:生物储备和组织保存的模型:病理实验室中档案样品中的RNA质量和裸鼠体内肿瘤异种移植物的“体内生物储备” —两种病理质量保证模型

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摘要

Tissue banks represent essential resources and platforms for biomedical research serving basic, translational, and clinical research projects. In this article, we describe 2 models of biobanking and tissue preservation with different approaches and aims. Archive tissue biobanking is described here as a resource of residual pathology tissues for translational research, which represents the huge clinical heterogeneity. In this context, managing of tissues and RNA quality in archive tissue are discussed. The other model of tissue biobanking is referred to as xenograft tissue banking, which represents an alternative method for obtaining large amounts of tissue, over an indefinite period, in so far as the tumor can be transferred in vivo over generations, maintaining the histological and genetic particularities. A description of the method and examples of the application are given with particular emphasis on sarcomas (Ewing’s sarcoma/primitive neuroectodermal sarcoma, synovial sarcomas, and rhabdomyosarcomas) and early stages of tumor angiogenesis in sarcomas.
机译:组织库代表了服务于基础,转化和临床研究项目的生物医学研究必不可少的资源和平台。在本文中,我们描述了两种具有不同方法和目的的生物库和组织保存模型。存档组织生物库在这里被描述为用于转化研究的残余病理组织资源,这代表了巨大的临床异质性。在这种情况下,讨论了组织管理和档案组织中的RNA质量。组织生物库的另一种模型称为异种移植组织库,这是一种可无限期获取大量组织的替代方法,只要该肿瘤可以在体内世代移植,并保持组织学和遗传学即可。特殊性。对该方法的描述和应用实例将重点放在肉瘤(尤因肉瘤/原始神经外胚层肉瘤,滑膜肉瘤和横纹肌肉瘤)以及肉瘤中肿瘤血管生成的早期阶段。

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