...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical and experimental pharmacology & physiology >Potential role of green tea catechins in various disease therapies: Progress and promise
【24h】

Potential role of green tea catechins in various disease therapies: Progress and promise

机译：绿茶儿茶素在各种疾病治疗中的潜在作用：进展与希望

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Green tea (from the plant Camellia sinensis), a beverage whose consumption started 5000 years ago in China, has important biological and pharmacological properties. The beneficial effects of green tea have been attributed to the presence of phenolic compounds that are powerful anti-oxidants and free iron scavengers. Of all the catechins found in green tea, namely (-)-epicatechin-3-gallate, (-)-epigallocatechin, (-)-epicatechin and (-)-epigallocatechin-3-gallate (EGCG), EGCG is the most abundant and powerful. It is widely believed that green tea may protect against death from all causes, especially cardiovascular diseases (coronary heart disease and stroke) owing to the presence of catechins associated with green tea consumption. Other health benefits include various types of cancer chemoprevention, weight loss and protective effects against neurodegenerative diseases (Alzheimer's disease and Parkinson's disease). Thus far, numerous pharmacological activities regulating disease-specific molecular targets have been reported in vitro for EGCG concentrations in the micromolar range, which are physiologically irrelevant. Although most of the studies have shown benefits with two to three cups of green tea per day, the optimal dose has not yet been established to enable any solid conclusions to be drawn regarding the various health benefits of green tea or its constituents in humans. With Phase I trials providing information on the safety profile and pharmacokinetics of EGCG, the window of opportunity is wider to undertake well-controlled long-term human studies to enable a full understanding of the protective effects of green tea catechins on various parameters in different settings.
机译：绿茶（来自山茶）是一种在中国已有5000多年历史的饮料，具有重要的生物学和药理特性。绿茶的有益作用归因于酚类化合物的存在，该化合物具有强大的抗氧化剂和游离铁清除剂的作用。在绿茶中发现的所有儿茶素中，（-）-表儿茶素-3-没食子酸酯，（-）-表儿茶素，（-）-表儿茶素和（-）-表没食子儿茶素-3-没食子酸酯（EGCG），其中EGCG含量最高和强大。人们普遍认为，由于与食用绿茶有关的儿茶素的存在，绿茶可以预防各种原因的死亡，尤其是心血管疾病（冠心病和中风）。其他健康益处包括各种类型的化学预防癌症，减肥和抗神经退行性疾病（阿尔茨海默氏病和帕金森氏病）的保护作用。迄今为止，已经报道了体外调节微摩尔范围内EGCG浓度的许多调节疾病特异性分子靶标的药理活性，这在生理上是不相关的。尽管大多数研究表明每天服用两到三杯绿茶是有好处的，但尚未确定最佳剂量，以就绿茶或其成分对人体的各种健康益处得出任何可靠的结论。随着I期试验提供有关EGCG的安全性和药代动力学的信息，进行良好控制的长期人体研究的机会之窗越来越广，从而可以全面了解绿茶儿茶素对不同环境中各种参数的保护作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号