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首页> 外文期刊>Clinica chimica acta: International journal of clinical chemistry and applied molecular biology >Evaluation of FibroTest inter-laboratory variations requires standardization on analytical systems and should not be mixed with underpowered histological validation.
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Evaluation of FibroTest inter-laboratory variations requires standardization on analytical systems and should not be mixed with underpowered histological validation.

机译：对FibroTest实验室间变异的评估要求对分析系统进行标准化，并且不应与动力不足的组织学验证混为一谈。

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摘要

In their recent article, Gressner et al. aimed to study the impact of inter-laboratory variations on liver biomarkers FibroTest-ActiTest (FT-AT) .The authors found that FT and AT scores were largely reproducible among six German laboratories, as previously reported among nine French laboratories .In the first part of the study, the authors assessed the intra-analytic variability of measurements still in the interval approved by the external quality control system (EQCS) of the German Society of Clinical Chemistry (DGKL). This was a theoretical analysis. Sixty-four FT-AT combinations were constructed using the parameter-specific sub-maximum and sub-minimum values within the accepted range of EQCS instead of the measured extreme values. The authors suggested that FT-AT accuracy based on extreme control values was laboratory-dependent. However, the characteristics of the EQCS material used are not described.
机译：在他们最近的文章中，Gressner等人。目的是研究实验室间变异对肝脏生物标志物FibroTest-ActiTest（FT-AT）的影响。作者发现，FT和AT分数在六个德国实验室中可重现，正如先前在九个法国实验室中所报道的那样。在这项研究中，作者评估测量的分析内变异性仍在德国临床化学学会（DGKL）的外部质量控制系统（EQCS）批准的区间内。这是理论分析。使用EQCS可接受范围内的特定于参数的次最大值和次最小值，而不是测量的极值，构建了64个FT-AT组合。作者认为，基于极端控制值的FT-AT准确性取决于实验室。然而，没有描述所使用的EQCS材料的特性。

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