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首页> 外文期刊>Computer Methods and Programs in Biomedicine: An International Journal Devoted to the Development, Implementation and Exchange of Computing Methodology and Software Systems in Biomedical Research and Medical Practice >Averaging in vitro cardiac field potential recordings obtained with microelectrode arrays.
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Averaging in vitro cardiac field potential recordings obtained with microelectrode arrays.

机译：用微电极阵列获得的平均体外心脏电场电势记录。

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摘要

Extracellular field potential (FP) recordings with microelectrode arrays (MEAs) from cardiomyocyte cultures offer a non-invasive way of studying the electrophysiological properties of these cells at the population level. Several studies have examined the FP properties of cardiomyocytes of various origins, including stem cell-derived cardiomyocytes. This focus reflects growing importance and interest in the field of MEA. High-quality cardiac FP signals are often difficult to obtain, especially from stem cell-derived cardiomyocyte cultures, which represent an important new field in cardiac electrophysiology. One way to improve the quality of these recordings is to average the cardiac FP signals. To date, however, no studies have examined the effect of averaging on cardiac FP signals. We report here that cardiac FP averaging can yield higher-quality signals than original individual FPs, and therefore promise more accurate detection of different phases and analysis of the cardiac FP signal. Averaged signals improved the signal-to-noise ratio (SNR), and obtaining reliable averages required approximately 50 cardiac cycles. We therefore propose that routine cardiac FP averaging can serve as a tool to compare the effects of different experimental conditions or stimuli on the properties of cardiac FPs.
机译：带有来自心肌细胞培养物的微电极阵列（MEA）的细胞外场电势（FP）记录，为研究这些细胞在群体水平上的电生理特性提供了一种非侵入性方式。几项研究检查了各种来源的心肌细胞的FP特性，包括干细胞衍生的心肌细胞。这种关注反映了在MEA领域中日益重要的地位和兴趣。高质量的心脏FP信号通常很难获得，尤其是从干细胞衍生的心肌细胞培养物中获得，这代表着心脏电生理学的一个重要新领域。改善这些记录质量的一种方法是平均心脏FP信号。然而，迄今为止，尚无研究检查平均对心脏FP信号的影响。我们在这里报告说，心脏FP平均可以产生比原始单个FP更高质量的信号，因此可以保证更准确地检测不同相位并分析心脏FP信号。平均信号改善了信噪比（SNR），并且获得可靠的平均值大约需要50个心动周期。因此，我们建议常规的心脏FP平均可以用作比较不同实验条件或刺激对心脏FPs特性的影响的工具。

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