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首页> 外文期刊>Biochimica et biophysica acta. Molecular basis of disease: BBA >The two faces of mast cells in food allergy and allergic asthma: The possible concept of Yin Yang
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The two faces of mast cells in food allergy and allergic asthma: The possible concept of Yin Yang

机译：食物过敏和过敏性哮喘中肥大细胞的两个面孔：阴阳的可能概念

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The purpose of this review is to discuss the role of mast cells in allergic inflammation. We have focused on inflammation associated with allergic asthma and food allergy. Mast cells are 'first line of defense' innate/adaptive immune cells and are widely distributed in tissues in surfaces exposed to the environment. Especially in allergic settings mast cells are extensively studied, as they can be activated to release a wide range of mediators by allergen-IgE specific triggers. In addition, in allergic inflammation mast cells can also be activated non-allergic triggers. Recent studies revealed that mast cells, besides the classical role of pro-inflammatory effector cell, have also emerged as modulators of allergic sensitization and down-regulators of allergic inflammation. Therefore, mast cells can be regarded as 'Ying Yan' modulators in allergic responses in intestinal tract and airways. This article is part of a Special Issue entitled: Mast Cells in Inflammation.
机译：这篇综述的目的是讨论肥大细胞在过敏性炎症中的作用。我们专注于与过敏性哮喘和食物过敏有关的炎症。肥大细胞是“第一道防线”的先天/适应性免疫细胞，广泛分布在暴露于环境的表面的组织中。特别是在过敏环境中，肥大细胞已被广泛研究，因为它们可以通过变应原-IgE特异性触发物激活以释放多种介体。此外，在变态反应性炎症中，肥大细胞也可被非变态性触发物激活。最近的研究表明，肥大细胞除了具有促炎效应细胞的经典作用外，还已经成为过敏性致敏的调节剂和过敏性炎症的下调剂。因此，肥大细胞可以被认为是肠道和气道过敏反应中的“鹰眼”调节剂。本文是名为“肥大细胞在炎症中”的特刊的一部分。

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