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Associations between fatty acids in colostrum and breast milk and risk of allergic disease.

机译：初乳和母乳中的脂肪酸之间的关联以及过敏性疾病的风险。

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BACKGROUND: Exposure to n-3 polyunsaturated fatty acids (PUFA) in early life is hypothesized to offer protection against atopic disease. However, there is controversy in this area, and we have previously observed that high levels of n-3 fatty acid (FA) in colostrum are associated with increased risk of allergic sensitization. OBJECTIVE: The aim of the study was to assess the relationship between FA profile in breast milk and risk of childhood atopic disease. METHODS: A high-risk birth cohort was recruited, and a total of 224 mothers provided a sample of colostrum (n=194) and/or 3-month expressed breast milk (n=118). FA concentrations were determined by gas chromatography. Presence of eczema, asthma and rhinitis were prospectively documented up to 7 years of age. RESULTS: High levels of n-3 22:5 FA (docosapentaenoic acid, DPA) in colostrum were associated with increased risk of infantile atopic eczema [odds ratio (OR)=1.66 per 1 standard deviation increase, 95% confidence interval (CI)=1.11-2.48], while total n-3 concentration in breast milk was associated with increased risk of non-atopic eczema (OR=1.60, 95% CI=1.03-2.50). Higher levels of total n-6 FA in colostrum were associated with increased risk of childhood rhinitis (OR=1.59, 95% CI=1.12-2.25). There was no evidence of associations between FA profile and risk of asthma. CONCLUSION: In this cohort of high-risk children, a number of modest associations were observed between FA concentrations in colostrum and breast milk and allergic disease outcomes. Further research in this area with larger sample sizes is needed.
机译：背景：据推测，在生命早期接触n-3多不饱和脂肪酸（PUFA）可以预防特应性疾病。然而，在这一领域存在争议，我们之前已经观察到初乳中高水平的n-3脂肪酸（FA）与过敏性致敏风险增加有关。目的：本研究的目的是评估母乳中FA的分布与儿童特应性疾病风险之间的关系。方法：招募了一个高危分娩队列，共有224名母亲提供了初乳样品（n = 194）和/或3个月表达的母乳（n = 118）。通过气相色谱法测定FA浓度。前瞻性地记录了直到7岁的湿疹，哮喘和鼻炎的存在。结果：初乳中高水平的n-3 22：5 FA（二十碳五烯酸，DPA）与婴儿异位性湿疹的风险增加相关[几率（OR）= 1.66，每增加1标准偏差，95％置信区间（CI） = 1.11-2.48]，而母乳中总n-3浓度与非特应性湿疹风险增加相关（OR = 1.60，95％CI = 1.03-2.50）。初乳中总n-6 FA含量较高与儿童鼻炎风险增加相关（OR = 1.59，95％CI = 1.12-2.25）。没有证据表明FA谱与哮喘风险之间存在关联。结论：在这一高危儿童队列中，初乳和母乳中FA浓度与过敏性疾病结局之间存在许多适度的关联。需要在此领域进行更大样本量的进一步研究。

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