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首页> 外文期刊>Clinical and experimental allergy : >Association between short sleep duration and the risk of sensitization to food and aero allergens in rural Chinese adolescents.
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Association between short sleep duration and the risk of sensitization to food and aero allergens in rural Chinese adolescents.

机译：中国农村青少年睡眠时间短与食物和空气过敏原致敏风险之间的关联。

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BACKGROUND: Both long and short sleep duration have been associated with obesity, cardiovascular disease, and diabetes. However, there have been no previous studies investigating the potential relationship between altered sleep duration and allergen sensitization. OBJECTIVE: To explore the association between sleep duration and sensitization to food and aeroallergens. METHODS: This study includes 1534 rural Chinese adolescent twins aged 12-21 years who completed standard sleep questionnaires and skin prick tests (SPTs) to nine food and five aeroallergens. Total sleep time was defined as the interval from bedtime to wake-up time minus sleep latency. Sensitization was defined as having at least one positive SPT. RESULTS: Compared with individuals with the highest (third) tertile of sleep duration, those who slept less were more likely to be sensitized to any food allergen with odds ratios (ORs) of 1.9 [95% confidence interval (CI): 1.3-2.7] and 1.4 (95% CI: 1.0-1.9) for the first and second tertiles (trend test P(trend)=3x10(-4)), respectively. The corresponding ORs for sensitization to any aeroallergen were 1.5 (95% CI: 1.1-2.0) and 1.3 (95% CI: 1.0-1.7) (P(trend)=8x10(-3)). These associations were independent of percent body fat. In addition, we observed a significant dose-response association between the number of positive SPTs and percentage of shortest sleep duration (first tertile) (P(trend)=1x10(-3)). CONCLUSIONS AND CLINICAL RELEVANCE: In this sample of relatively lean rural Chinese adolescents, we found that short sleep duration was associated with increasing risk of sensitization to food and aeroallergens, independent of percent body fat. Longitudinal studies are needed to further determine the temporal and causal relationships. If short sleep duration indeed is one of the risk factors for allergic sensitization, the global burden of allergic diseases could be dramatically reduced by providing appropriate guidance on sleep duration for youth.
机译：背景：长期和短暂的睡眠时间都与肥胖，心血管疾病和糖尿病有关。但是，以前没有研究调查改变睡眠时间和过敏原致敏之间的潜在关系。目的：探讨睡眠时间与食物和空气过敏原敏感性之间的关系。方法：本研究包括1534名12-21岁的中国农村青少年双胞胎，他们完成了标准的睡眠调查表和9种食物和5种气敏性过敏原的皮肤点刺试验（SPT）。总睡眠时间定义为从上床时间到醒来时间的间隔减去睡眠潜伏期。敏化被定义为具有至少一个阳性SPT。结果：与睡眠时间最高（第三）的人相比，睡眠时间短的人更有可能对食物过敏原敏感，其比值比（OR）为1.9 [95％置信区间（CI）：1.3-2.7 ]和1.4（95％CI：1.0-1.9）分别用于第一和第二个三分位数（趋势测试P（趋势）= 3x10（-4））。对任何气变应原致敏的相应OR为1.5（95％CI：1.1-2.0）和1.3（95％CI：1.0-1.7）（P（趋势）= 8x10（-3））。这些关联与体脂百分比无关。此外，我们观察到阳性SPT数量与最短睡眠时间百分比（第一三分位数）之间存在显着的剂量反应关系（P（趋势）= 1x10（-3））。结论和临床意义：在这个相对较瘦的中国农村青少年样本中，我们发现睡眠时间短与增加对食物和空气过敏原的致敏风险有关，而与体脂百分比无关。需要进行纵向研究以进一步确定时间和因果关系。如果睡眠时间短确实是变态反应致敏的危险因素之一，则可以通过提供有关青少年睡眠时间的适当指导来显着降低过敏性疾病的全球负担。

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