• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical and experimental allergy : >AluyMICB dimorphism within the class I region of the major histocompatibility complex is associated with asthma and airflow obstruction in the Busselton population.
【24h】

AluyMICB dimorphism within the class I region of the major histocompatibility complex is associated with asthma and airflow obstruction in the Busselton population.

机译：主要组织相容性复合体I类区域内的AluyMICB二态性与Busselton人群的哮喘和气流阻塞有关。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aim To examine the association between the Alu dimorphism within the first intron of the MICB gene and asthma and airflow obstruction. Background The highly polymorphic non-classical MHC class I polypeptide-related (MIC) genes, MICA and MICB, encode stress inducible glycoproteins, which are expressed on a variety of epithelial cells, including those of the lungs. Methods AluyMICB genotyping was performed on 1109 subjects from the Busselton Health Study. From a standard questionnaire, 359 individuals indicated that they had been diagnosed by a doctor with asthma. Lung function was assessed by the forced expired volume in 1 second (FEV(1)) and expressed as a percent of the predicted value. Airflow obstruction was defined as FEV(1)<80% predicted. Results In men, a dominant relationship was found between the AluyMICB DD genotype and asthma (P=0.006; chi(2) (2)=7.65). Furthermore, multivariate analysis adjusted for age, height, weight and body mass index (BMI) showed a relationship between DD genotype and asthma in men in a dominant model (odds ratio (OR)=1.97; 95% confidence interval (CI)=1.11-3.51; P=0.021). In women, an association was found between the AluyMICB II genotype and FEV(1) percent predicted as a continuous variable (P=0.001). When adjusted for age and BMI, it showed a significant relationship between AluyMICB and airflow obstruction in a dominant model (OR=14.11%, 95% CI 3.29-60.57, P<0.001). However, no association was found between the AluyMICB II genotypes and airflow obstruction in men. Conclusion These findings suggest the possible involvement of a MHC class I gene in abnormal airway structure in women and airway function in men.
机译：目的探讨MICB基因第一个内含子内Alu二态性与哮喘和气流阻塞之间的关系。背景技术高度多态的非经典MHC I类多肽相关（MIC）基因，MICA和MICB，编码应激诱导糖蛋白，在多种上皮细胞（包括肺上皮细胞）中表达。方法对来自Busselton Health Study的1109名受试者进行AluyMICB基因分型。从标准问卷中，有359人表示他们已被哮喘医生诊断。肺功能通过1秒内的强制呼气量（FEV（1））进行评估，并表示为预测值的百分比。气流阻塞的定义为FEV（1）<预测的80％。结果在男性中，AluyMICB DD基因型与哮喘之间存在显着关系（P = 0.006; chi（2）（2）= 7.65）。此外，针对年龄，身高，体重和体重指数（BMI）进行的多元分析显示，在显性模型中，男性的DD基因型与哮喘之间存在相关性（优势比（OR）= 1.97; 95％置信区间（CI）= 1.11）。 -3.51; P = 0.021）。在女性中，发现AluyMICB II基因型与FEV（1）百分比之间的关联被预测为连续变量（P = 0.001）。调整年龄和BMI后，在显性模型中显示AluyMICB与气流阻塞之间存在显着关系（OR = 14.11％，95％CI 3.29-60.57，P <0.001）。但是，在男性中AluyMICB II基因型与气流阻塞之间没有关联。结论这些发现表明，MHC I类基因可能与女性气道结构异常以及男性气道功能有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号