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Fishing for allergy prevention

机译：钓鱼预防过敏

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The long chain, highly unsaturated omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are found in oily fish such as salmon, mackerel, herring and sardines and in fish oil supplements [1]. These fatty acids are known to modify immune function and inflammatory processes [2, 3] and may play a role in prevention and treatment of allergy [4]. In the current issue, van den Elsen et al. describe an effect of dietary omega-3 fatty acids on immune cell phenotypes and immune responses in young mice sensitized to whey protein, as a model of cows' milk allergy [5]. Importantly, the fatty acids were fed before and during sensi-tization, revealing a potential impact on primary prevention of allergy. The control mice were fed a diet where the fat was provided as soybean oil, rich in the omega-6 fatty acid linoleic acid. This appears to be the first examination of dietary fatty acids in this model, although an earlier study in ovalbumin-sensitized mice revealed a protective effect of dietary omega-3 fatty acids [6]. van den Elsen et al. report that dietary fish oil decreases serum anti-whey IgE, IgG1 and IgG2a concentrations and the number of activated Thl and Th2 cells in the spleen and, less convincingly, in mesenteric lymph nodes [5].
机译：长链高度不饱和的omega-3脂肪酸二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）存在于鲑鱼，鲭鱼，鲱鱼和沙丁鱼等油性鱼以及鱼油补品中[1]。已知这些脂肪酸可改变免疫功能和炎症过程[2，3]，并可能在过敏的预防和治疗中发挥作用[4]。在本期杂志中，van den Elsen等。描述了饮食中的ω-3脂肪酸对乳清蛋白敏感的幼鼠免疫细胞表型和免疫应答的作用，作为牛乳过敏的模型[5]。重要的是，在敏化之前和敏化过程中进食了脂肪酸，显示出对一级预防过敏的潜在影响。给对照小鼠喂食，其中脂肪以大豆油形式提供，富含omega-6脂肪酸亚油酸。这似乎是该模型中饮食脂肪酸的首次检查，尽管对卵白蛋白致敏小鼠的早期研究显示了饮食中ω-3脂肪酸的保护作用[6]。 van den Elsen等。报告指出，日粮鱼油可降低血清抗乳清IgE，IgG1和IgG2a的浓度，并降低脾脏中和肠系膜淋巴结中活化的Th1和Th2细胞的数量[5]。

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