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首页> 外文期刊>Clinical and experimental allergy : >Adipokines in cord blood and risk of wheezing disorders within the first two years of life.
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Adipokines in cord blood and risk of wheezing disorders within the first two years of life.

机译：生命的头两年内脐带血中的脂肪因子和发生喘息的风险。

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BACKGROUND: Adipokines are involved in the regulation of many inflammatory processes and are present at very high concentrations in cord blood of term infants. OBJECTIVE: We analysed data of a large prospective birth cohort study to examine whether adiponectin and leptin concentration in cord blood are determinants of wheezing disorders in children within the first 2 years of life. METHODS: Seven hundred and forty mothers and their newborns were included in this analysis. Adiponectin and leptin concentrations were measured in cord blood. The cumulative incidence of physician-reported asthma or obstructive bronchitis was recorded during a 2-year follow-up. RESULTS: During the first 2 years of life, asthma or obstructive bronchitis was reported by the caring paediatricians for 157 (19.6%) of the children. We found a strong interaction of cord blood adiponectin and history of atopic disease in the mother with respect to the risk of physician-reported asthma or obstructive bronchitis (P=0.006). Compared with children with cord blood levels in the middle quintile (reference category), the odds ratios for physician-reported asthma or obstructive bronchitis in the bottom quintile and top quintile were 0.14 [95% confidence interval (CI) 0.02-0.90] and 2.12 (95% CI 0.67-6.66), respectively (P for trend=0.0003), among children of mothers with a history of atopy. This association was independent of other established risk factors. Leptin levels in cord blood were not associated with risk of asthma or obstructive bronchitis. CONCLUSIONS: In children of mothers with a history of atopy, concentrations of adiponectin in cord blood could play an important role in determining risk of wheezing disorders in early childhood.
机译：背景：脂肪因子参与许多炎症过程的调节，足月儿的脐带血中存在很高的浓度。目的：我们分析了一项大型前瞻性出生队列研究的数据，以检查脐带血中脂联素和瘦素的浓度是否是儿童出生后头2年内喘息障碍的决定因素。方法：本研究纳入了740名母亲及其新生儿。在脐带血中测量脂联素和瘦素的浓度。在两年的随访中记录了医生报告的哮喘或阻塞性支气管炎的累积发生率。结果：在有生命的头2年中，有爱心的儿科医生报告了157名儿童（19.6％）患有哮喘或阻塞性支气管炎。我们发现，在医生报告的哮喘或阻塞性支气管炎风险方面，母亲的脐血脂联素与特应性病史之间存在很强的相互作用（P = 0.006）。与中五分位数的脐带血儿童相比（参考类别），医生报告的下五分位数和上五分位数的哮喘或阻塞性支气管炎的优势比为0.14 [95％置信区间（CI）0.02-0.90]和2.12患有特应性史的母亲的孩子中（95％CI 0.67-6.66）（趋势的P = 0.0003）。这种关联独立于其他确定的风险因素。脐带血中的瘦素水平与哮喘或阻塞性支气管炎的风险无关。结论：在患有特应性史的母亲的孩子中，脐带血中脂联素的浓度可能在确定儿童早期喘息障碍的风险中起重要作用。

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