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首页> 外文期刊>Comparative Immunology, Microbiology and Infectious Diseases >Identification of full-length proviral DNA of porcine endogenous retrovirus from Chinese Wuzhishan miniature pigs inbred.
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Identification of full-length proviral DNA of porcine endogenous retrovirus from Chinese Wuzhishan miniature pigs inbred.

机译：中国五指山小型猪近交猪内源性逆转录病毒全长原病毒DNA的鉴定。

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摘要

Existence of porcine endogenous retrovirus (PERV) hinders pigs to be used in clinical xenotransplantation to alleviate the shortage of human transplants. Chinese miniature pigs are potential organ donors for xenotransplantation in China. However, so far, an adequate level of information on the molecular characteristics of PERV from Chinese miniature pigs has not been available. We described here the cloning and characterization of full-length proviral DNA of PERV from Chinese Wuzhishan miniature pigs inbred (WZSP). Full-length nucleotide sequences of PERV-WZSP and other PERVs were aligned and phylogenetic tree was constructed from deduced amino-acid sequences of env. The results demonstrated that the full-length proviral DNA of PERV-WZSP belongs to gammaretrovirus and shares high similarity with other PERVs. Sequence analysis also suggested that different patterns of LTR existed in the same porcine germ line and partial PERV-C sequence may recombine with PERV-A sequence in LTR.
机译：猪内源性逆转录病毒（PERV）的存在阻碍了猪用于临床异种移植，以减轻人类移植物的短缺。中国小型猪是中国异种移植的潜在器官供体。但是，到目前为止，关于中国小型猪PERV分子特征的信息尚不充分。我们在这里描述了来自中国五指山微型猪近交系（WZSP）的PERV全长原病毒DNA的克隆和表征。将PERV-WZSP和其他PERV的全长核苷酸序列进行比对，并根据推导的 env 氨基酸序列构建系统树。结果表明，PERV-WZSP的全长原病毒DNA属于γ逆转录病毒，与其他PERV具有高度相似性。序列分析还表明，同一猪种系中存在不同的LTR模式，部分PERV-C序列可能与LTR中的PERV-A序列重组。

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