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Functional and clinical insights from neuroimaging studies in childhood-onset schizophrenia

机译：神经影像学研究对儿童期精神分裂症的功能和临床见解

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Childhood-onset schizophrenia is a rare pediatric onset psychiatric disorder continuous with and typically more severe than its adult counterpart. Neuroimaging research conducted on this population has revealed similarly severe neural abnormalities. When taken as a whole, neuroimaging research in this population shows generally decreased cortical gray matter coupled with white matter connectivity abnormalities, suggesting an anatomical basis for deficits in executive function. Subcortical abnormalities are pronounced in limbic structures, where volumetric deficits are likely related to social skill deficits, and cerebellar deficits that have been correlated to cognitive abnormalities. Structures relevant to motor processing also show a significant alteration, with volumetric increase in basal ganglia structures likely due to antipsychotic administration. Neuroimaging of this disorder shows an important clinical image of exaggerated cortical loss, altered white matter connectivity, and differences in structural development of subcortical areas during the course of development and provides important background to the disease state.
机译：儿童期精神分裂症是一种罕见的小儿发作性精神病，其持续性通常比其成年精神病严重。对这一人群进行的神经影像学研究发现了类似的严重神经异常。从整体上看，该人群的神经影像学研究显示皮质灰质普遍减少，伴有白质连通性异常，这提示执行功能缺陷的解剖学基础。皮质下异常在边缘结构中很明显，其中体积不足很可能与社交技能不足有关，而小脑不足则与认知异常有关。与运动处理有关的结构也显示出明显的变化，可能由于抗精神病药物的给药导致神经节结构的体积增加。这种疾病的神经影像学表现出重要的临床影像，即皮质皮质丧失，白质连接性改变以及皮质在皮层下区域的结构发育在发育过程中的差异，并为疾病状态提供了重要背景。

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