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Insights revealed by rodent models of sugar binge eating

机译：啮齿动物暴食糖模型揭示的见解

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摘要

Binge eating is seen across the spectrum of eating disorder diagnoses as well as among individuals who do not meet diagnostic criteria. Analyses of the specific types of foods that are frequently binged upon reveal that sugar-rich items feature prominently in binge-type meals, making the effects of binge consumption of sugar an important focus of study. One avenue to do this involves the use of animal models. Foundational and recent studies of animal models of sugar bingeing, both outlined here, lend insight into the various neurotransmitters and neuropeptides that may participate in or be altered by this behavior. Further, several preclinical studies incorporating sugar bingeing paradigms have explored the utility of pharmacological agents that target such neural systems for reducing sugar bingeing in an effort to enhance clinical treatment. Indeed, the translational implications of findings generated using animal models of sugar bingeing are considered here, along with potential avenues for further study.
机译：在饮食失调诊断的各个方面以及不符合诊断标准的个体中都可以看到暴饮暴食。对经常食用的特定食物类型的分析表明，暴食型膳食中富含糖分的食物具有显着特征，因此，暴食食糖的影响成为研究的重要重点。一种实现方法涉及使用动物模型。糖暴食动物模型的基础研究和最新研究（均在此处概述）有助于深入了解可能参与这种行为或被这种行为改变的各种神经递质和神经肽。此外，一些结合糖暴食范例的临床前研究已经探索了针对此类神经系统的药理学试剂的效用，以减少糖暴饮，以增强临床治疗。的确，这里考虑了使用糖暴饮动物模型产生的发现的翻译含义，以及可能的进一步研究途径。

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