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首页> 外文期刊>Biophysics >Autowave Mechanisms of Electrocardiographic Variability during High-Frequency Arrhythmias: A Study by Mathematical Modeling
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Autowave Mechanisms of Electrocardiographic Variability during High-Frequency Arrhythmias: A Study by Mathematical Modeling

机译：高频心律失常期间心电图变异性的自动波机制：数学建模的研究。

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摘要

High-frequency cardiac arrhythmias pose a high risk of sudden death. Their usual cause is the emergence of rotating autowaves. The Aliev.Panfilov model was used (i) to describe the dynamics of a rotating three-dimensional scroll-shaped excitation wave in homogeneous and heterogeneous media and (ii) to relate its dynamics to the results of normalized variability analysis (our variant of rescaled range analysis for electrocardiography; Moskalenko et al., Biofizika, 2001, vol. 46, no. 2, pp. 319.329) of model electrocardiograms obtained by summing local membrane potentials. In a homogeneous medium, the stability of a scroll wave against filament shape change was shown to depend on the excitability of the medium and on the filament tension. Scroll waves arising in inhomogeneous media were usually unstable. The dynamics of a three-dimensional scroll-shaped excitation wave was significantly related to the variability indices of model electrocardiograms. Higher excitation thresholds of the medium corresponded to larger variability indices. It was also found that at certain parameters the indices of electrocardiographic variability were larger in the homogeneous than in the inhomogeneous medium.
机译：高频心律不齐导致猝死的高风险。它们的常见原因是旋转自动波的出现。使用Aliev.Panfilov模型（i）描述均质和非均质介质中旋转的三维涡旋形激发波的动力学，以及（ii）将其动力学与归一化变异性分析的结果（我们重新定标的变体）相关心电图的范围分析; Moskalenko等人，Biofizika，2001，第46卷，第2期，第319.329页）是通过汇总局部膜电位而获得的模型心电图。在均匀的介质中，涡旋波对细丝形状变化的稳定性显示出取决于介质的兴奋性和细丝张力。在不均匀介质中产生的涡旋波通常是不稳定的。三维涡旋形激励波的动力学与模型心电图的变异性指数显着相关。介质的较高激发阈值对应于较大的可变性指数。还发现，在某些参数下，均匀介质中的心电图变异性指数大于不均匀介质中的。

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