Microwave-assisted synthesis of N-substituted cyclic imides and their evaluation for anticancer and anti-inflammatory activities.

Sondhi SM; Rani R; Roy P; Agrawal SK; Saxena AK

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Microwave-assisted synthesis of N-substituted cyclic imides and their evaluation for anticancer and anti-inflammatory activities.

机译：微波辅助合成N-取代的环酰亚胺及其抗癌和抗炎活性的评估。

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A number of N-substituted cyclic imides 3a-e, 5a-e, 7a-d, and 9a-e have been synthesized in very high yields, by condensation of various diacids 2, 4, 6, and 8 with different amines under microwave irradiation. These compounds were screened for anticancer and anti-inflammatory activities, and compounds 3c, 3e, 5c, 9c, and 9d exhibited anticancer activity against colon (COLO 205) cancer better than 5-fluorouracil and mitomycin-C, and compound 9b exhibited anti-inflammatory activity better than standard drug phenyl butazone.

机译：通过在微波下将各种二酸2、4、6和8与不同的胺缩合，以很高的收率合成了许多N-取代的环状酰亚胺3a-e，5a-e，7a-d和9a-e。辐射。筛选了这些化合物的抗癌和抗炎活性，化合物3c，3e，5c，9c和9d对结肠癌（COLO 205）的抗癌活性优于5-氟尿嘧啶和丝裂霉素C，而化合物9b对5-炎症活性优于标准药物苯基丁but。

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《Bioorganic and Medicinal Chemistry Letters》 |2009年第5期|共5页
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Sondhi SM; Rani R; Roy P; Agrawal SK; Saxena AK;
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1. Microwave-assisted synthesis of N-substituted cyclic imides and their evaluation for anticancer and anti-inflammatory activities. [J] . Sondhi SM, Rani R, Roy P, Bioorganic and Medicinal Chemistry Letters . 2009,第5期

机译：微波辅助合成N-取代的环酰亚胺及其抗癌和抗炎活性的评估。
2. Microwave-assisted synthesis of benzenesulfonohydrazide and benzenesulfonamide cyclic imide hybrid molecules and their evaluation for anticancer activity [J] . Kumar Anuj, Kumar Nikhil, Roy Partha, Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents . 2015,第10期

机译：微波辅助合成苯磺酰肼与苯磺酰胺环状酰亚胺杂化分子及其抗癌活性的评价
3. Synthesis and biological evaluation of a series of multi-target N-substituted cyclic imide derivatives with potential antipsychotic effect [J] . Mingshuo Xu, Yu Wang, Feipu Yang, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2018,第期

机译：具有潜在抗精神病效应的一系列多靶N-取代的循环酰亚胺衍生物的合成与生物学评价
4. Negative chemical amplification resist systems based on polyhydroxystyrenes and N-substituted imides or aldehydes [C] . Hiroshi Ito, IBM/Almaden Research Ctr., San Jose, Advances in Resist Technology and Processing VIII . 1991

机译：基于聚羟基苯乙烯和N-取代的酰亚胺或醛的负化学放大抗蚀剂系统
5. Design and synthesis of novel anti-inflammatory lipid mediators and anticancer small molecules. [D] . Uddin, Jasim. 2008

机译：新型抗炎脂质介体和抗癌小分子的设计与合成。
6. Synthesis anti-inflammatory cytotoxic and COX-1/2 inhibitory activities of cyclic imides bearing 3-benzenesulfonamide oxime and β-phenylalanine scaffolds: a molecular docking study [O] . Alaa A.-M. Abdel-Aziz, Adel S. El-Azab, Nawaf A. AlSaif, 2020

机译：带有3-苯磺酰胺肟和β-苯丙氨酸支架的环状酰亚胺的合成抗炎细胞毒性和COX-1 / 2抑制活性：分子对接研究
7. Synthesis and Anxiolytic Activity of N-Substituted Cyclic Imides(1R*,2S*,3R*,4S*)-N-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)butyl)-2,3-bicyclo(2.2.1)heptanedicarboximide(Tandospirone) and Related Compounds. [O] . Kikuo ISHIZUMI, Atsuyuki KOJIMA, Fujio ANTOKU 1991

机译：N-取代的环酰亚胺的合成和抗焦力活性（1R *，2S *，3R *，4S *） - N-（4-（4-（2-（2-（2-嘧啶基）-1-哌嗪基）丁基）-2,3-双环（2.2.1）庚烷二羧基酰亚胺（TANDOSPIRONE）和相关化合物。

Microwave-assisted synthesis of N-substituted cyclic imides and their evaluation for anticancer and anti-inflammatory activities.

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