Pyrazole derivatives from azines of substituted phenacyl aryl/cyclohexyl sulfides and their antimycobacterial activity.

Manikannan R; Venkatesan R; Muthusubramanian S; Yogeeswari P; Sriram D

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Pyrazole derivatives from azines of substituted phenacyl aryl/cyclohexyl sulfides and their antimycobacterial activity.

机译：取代的苯甲酰基芳基/环己基硫醚的吡唑衍生物及其抗分枝杆菌活性。

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摘要

Azines derived from substituted phenacyl aryl/cyclohexyl sulfide on treatment with excess phosphorous oxychloride in N,N-dimethylformamide have been found to yield two isomeric pyrazoles in each case. A plausible mechanism has been suggested for the formation of the products. The antimycobacterial activity of the isomeric compounds has been tested against Mycobacterium tuberculosis (MTB).

机译：已发现在N，N-二甲基甲酰胺中用过量的三氯氧化磷处理衍生自取代的苯甲酰基芳基/环己基硫化物的derived嗪在每种情况下均会产生两种异构的吡唑。已经提出了一种可能的机制来形成产物。已测试了同分异构化合物的抗分枝杆菌活性，可抵抗结核分枝杆菌（MTB）。

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《Bioorganic and Medicinal Chemistry Letters》 |2010年第23期|共5页
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Manikannan R; Venkatesan R; Muthusubramanian S; Yogeeswari P; Sriram D;
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1. Pyrazole derivatives from azines of substituted phenacyl aryl/cyclohexyl sulfides and their antimycobacterial activity. [J] . Manikannan R, Venkatesan R, Muthusubramanian S, Bioorganic and Medicinal Chemistry Letters . 2010,第23期

机译：取代的苯甲酰基芳基/环己基硫醚的吡唑衍生物及其抗分枝杆菌活性。
2. Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation [J] . Ismail M. Taban, Hosam E. A. E. Elshihawy, Beyza Torun, Journal of Medicinal Chemistry . 2017,第24期

机译：新型芳基取代的吡唑作为细胞色素P450CYP121A1的小分子抑制剂：合成和抗微生物评估
3. Design, synthesis and antimycobacterial evaluation of novel 3-substituted-N-aryl-6,7-dimethoxy-3a,4-dihydro-3H-indeno(1,2-c)pyrazole-2-carbox amide analogues. [J] . Ahsan MJ, Samy JG, Dutt KR, Bioorganic and Medicinal Chemistry Letters . 2011,第15期

机译：新型3-取代-N-芳基-6,7-二甲氧基-3a，4-二氢-3H-茚并（1,2-c）吡唑-2-羧酰胺类似物的设计，合成和抗分枝杆菌评估。
4. Syntheses, Structure and Herbicidal Activity of Substituted Phenyl Pyrazole Derivatives [C] . The 12th Asian Pacific Confederation of Chemical Engineering Congress(第十二届亚太化工联盟大会暨化工展览会)论文集 . 2008

机译：取代的苯基吡唑衍生物的合成，结构和除草活性
5. Hypercoordinate silicon compounds in organic synthesis: Improved methods for the synthesis of aryl(trialkoxy)silane derivatives; and trimethylsilyl cyanide as a cyanide source for nucleophilic substitution. [D] . Manoso, Amy Slover. 2004

机译：有机合成中的超配位硅化合物：合成芳基（三烷氧基）硅烷衍生物的改进方法；三甲基甲硅烷基氰化物作为亲核取代的氰化物来源。
6. Design Synthesis and Anti-Tobacco Mosaic Virus (TMV) Activity of 5-Chloro-N-(4-cyano-1-aryl-1H-pyrazol-5-yl)-1-aryl-3-methyl-1H-pyrazole-4-carboxamide Derivatives [O] . Jin-Jing Xiao, Min Liao, Ming-Jie Chu, 2015

机译：5-氯-N-（4-氰基-1-芳基-1H-吡唑-5-基）-1-芳基-3-甲基-1H-吡唑-的设计合成及抗烟草花叶病毒（TMV）活性4-羧酰胺衍生物
7. Kinetic Study on the Reaction of (Arylthio)trimethylsilanes with Phenacyl Bromide Giving Aryl Phenacyl Sulfides and Bromotrimethylsilane [O] . Seizi Kozuka, Tetsuji Higashino, Takuro Kitamura 1981

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8. Organophosphazenes. XIV. Para Substituted Aryl and Mixed Para Substituted Aryl/Phenyl Fluorocyclotriphosphazene Derivatives [R] . Allen, C. W., Brunst, G. E., Perlman, M. E. 1980

机译：有机磷腈。十四。对位取代的芳基和混合对位取代的芳基/苯基氟代环三磷腈衍生物

Pyrazole derivatives from azines of substituted phenacyl aryl/cyclohexyl sulfides and their antimycobacterial activity.

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