Non-competitive and selective dipeptidyl peptidase IV inhibitors with phenethylphenylphthalimide skeleton derived from thalidomide-related alpha-glucosidase inhibitors and liver X receptor antagonists.

Motoshima K; Sugita K; Hashimoto Y; Ishikawa M

首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >Non-competitive and selective dipeptidyl peptidase IV inhibitors with phenethylphenylphthalimide skeleton derived from thalidomide-related alpha-glucosidase inhibitors and liver X receptor antagonists.

【24h】

Non-competitive and selective dipeptidyl peptidase IV inhibitors with phenethylphenylphthalimide skeleton derived from thalidomide-related alpha-glucosidase inhibitors and liver X receptor antagonists.

机译：具有沙利度胺相关的α-葡萄糖苷酶抑制剂和肝X受体拮抗剂衍生的具有苯乙基苯基邻苯二甲酰亚胺骨架的非竞争性和选择性二肽基肽酶IV抑制剂。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Novel dipeptidyl peptidase IV (DPP-IV) inhibitors with a phenethylphenylphthalimide skeleton were prepared based on alpha-glucosidase inhibitors and liver X receptor (LXR) antagonists derived from thalidomide. Representative compounds showed non-competitive inhibition of DPP-IV and 28a exhibited 10-fold selectivity for DPP-IV over DPP-8. Compound 28a is the first non-competitive, selective DPP-IV inhibitor.

机译：基于α-葡萄糖苷酶抑制剂和沙利度胺衍生的肝X受体（LXR）拮抗剂，制备了具有苯乙基苯基邻苯二甲酰亚胺骨架的新型二肽基肽酶IV（DPP-IV）抑制剂。代表性化合物显示出对DPP-IV的非竞争性抑制作用，并且28a对DPP-IV的选择性是DPP-8的10倍。化合物28a是第一种非竞争性选择性DPP-IV抑制剂。

著录项

来源
《Bioorganic and Medicinal Chemistry Letters》 |2011年第10期|共5页
作者
Motoshima K; Sugita K; Hashimoto Y; Ishikawa M;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类
关键词

相似文献

外文文献
中文文献
专利

1. Non-competitive and selective dipeptidyl peptidase IV inhibitors with phenethylphenylphthalimide skeleton derived from thalidomide-related alpha-glucosidase inhibitors and liver X receptor antagonists. [J] . Motoshima K, Sugita K, Hashimoto Y, Bioorganic and Medicinal Chemistry Letters . 2011,第10期

机译：具有沙利度胺相关的α-葡萄糖苷酶抑制剂和肝X受体拮抗剂衍生的具有苯乙基苯基邻苯二甲酰亚胺骨架的非竞争性和选择性二肽基肽酶IV抑制剂。
2. Peroxisome proliferator-activated receptor agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related liver X receptor antagonists: relationship between absolute configuration and subtype selectivity. [J] . Motoshima K, Ishikawa M, Hashimoto Y, Bioorganic and medicinal chemistry . 2011,第10期

机译：过氧化物酶体增殖物激活的受体激动剂，与来自沙利度胺相关的肝X受体拮抗剂的苯乙基苯基邻苯二甲酰亚胺骨架：绝对构型与亚型选择性之间的关系。
3. Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors. [J] . Noguchi-Yachide T, Aoyama A, Makishima M, Bioorganic and Medicinal Chemistry Letters . 2007,第14期

机译：具有由沙利度胺相关的葡糖苷酶抑制剂衍生的邻苯二甲酰亚胺骨架的肝X受体拮抗剂。
4. Classification analysis using support vector machine, decision tree, and neural network with principal component analysis to determine molecular structure relationship from its biological activity on dipeptidyl peptidase IV inhibitors [C] . Haris Hamzah, Alhadi Bustamam, Arry Yanuar, International Conference on Science and Applied Science . 2020

机译：使用支撑向量机，决策树和神经网络具有主成分分析的分类分析，从而确定二肽基肽酶IV抑制剂的生物活性分子结构关系
5. Screening, Extraction, Isolation and Characterization of a Dipeptidyl Peptidase-IV (DPP-IV) Inhibitor From Ayurvedic and Chinese Herbs [D] . Dai, Fangteng 2018

机译：阿育吠陀和中草药中二肽基肽酶-IV（DPP-IV）抑制剂的筛选，提取，分离和表征
6. An angiotensin-converting enzyme inhibitor modulates stromal-derived factor-1 through CD26/dipeptidyl peptidase IV to inhibit laser-induced choroidal neovascularization [O] . Hong Li, Yu-sheng Wang 2013

机译：血管紧张素转换酶抑制剂通过CD26 /二肽基肽酶IV调节基质衍生因子-1以抑制激光诱导的脉络膜新生血管形成
7. Glycogen Phosphorylase a Inhibitors with a Phenethylphenylphthalimide Skeleton Derived from Thalidomide-Related .ALPHA.-Glucosidase Inhibitors and Liver X Receptor Antagonists [O] . Kazunori Motoshima, Minoru Ishikawa, Kazuyuki Sugita, 2009

机译：糖原磷酸化酶抑制剂与衍生自三度胺类相关的α-葡萄糖酶抑制剂和肝X受体拮抗剂的苯乙烯苯基苯二甲酰氯骨架骨架

Non-competitive and selective dipeptidyl peptidase IV inhibitors with phenethylphenylphthalimide skeleton derived from thalidomide-related alpha-glucosidase inhibitors and liver X receptor antagonists.

摘要

著录项

相似文献

相关主题

期刊订阅