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首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >Microwave-assisted efficient conjugation of nanodiamond and paclitaxel
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Microwave-assisted efficient conjugation of nanodiamond and paclitaxel

机译:微波辅助纳米金刚石与紫杉醇的有效结合

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Nanodiamond has recently received considerable attention due to the various possible applications in medical field such as drug delivery and bio-labeling. For this purpose suitable and effective surface functionalization of the diamond material are required. A versatile and reproducible surface modification method of nanoscale diamond is essential for functionalization. We introduce the input of microwave energy to assist the functionalization of nanodiamond surface. The feasibility of such a process is illustrated by comparing the biological assay of ND-paclitaxel synthesized by conventional and microwave irradiating. Using a microwave we manage to have approximately doubled grafted molecules per nanoparticle of nanodiamond. (C) 2015 Elsevier Ltd. All rights reserved.
机译:由于在医学领域中的各种可能的应用,例如药物递送和生物标记,纳米金刚石最近受到了相当大的关注。为此,需要金刚石材料的合适和有效的表面功能化。纳米级金刚石的通用且可重现的表面改性方法对于功能化至关重要。我们介绍了微波能量的输入,以辅助纳米金刚石表面的功能化。通过比较常规照射和微波照射合成的ND-紫杉醇的生物学分析,说明了该方法的可行性。使用微波,我们设法使每个纳米金刚石纳米颗粒的接枝分子增加约一倍。 (C)2015 Elsevier Ltd.保留所有权利。

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