Synthesis, nematocidal activity and docking study of novel chiral 1-(3-chloropyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide derivatives

Liu Xing-Hai; Zhao Wen; Shen Zhong-Hua; Xing Jia-Hua; Yuan Jing; Yang Guo; Xu Tian-Ming; Peng Wei-Li

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Synthesis, nematocidal activity and docking study of novel chiral 1-(3-chloropyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide derivatives

机译：新型手性1-（3-氯吡啶-2-基）-3-（三氟甲基）-1H-吡唑-4-羧酰胺衍生物的合成，杀线活性和对接研究

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A series of novel chiral fluorinated pyrazole carboxamides derivatives were designed and synthesized. All these title compounds were confirmed by NMR and MS. The primarily nematocidal activity results indicated that some of them exhibited good control efficacy against the tomato root-knot nematode disease caused by Meloidogyne incognita. The docking results indicated that compound 5n interact with amino acid residue Tyr 121, Trp 279 of AchE via hydrogen bond. (C) 2016 Elsevier Ltd. All rights reserved.

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《Bioorganic and Medicinal Chemistry Letters》 |2016年第15期|共3页
作者
Liu Xing-Hai; Zhao Wen; Shen Zhong-Hua; Xing Jia-Hua; Yuan Jing; Yang Guo; Xu Tian-Ming; Peng Wei-Li;
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正文语种 eng
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关键词
Trifluoromethylpyrazole; Chiral chain; Nematocidal activity; Synthesis; Docking;

机译：三氟甲基吡唑;手性链;杀线活性;合成;对接;

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1. Synthesis, nematocidal activity and docking study of novel chiral 1-(3-chloropyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide derivatives [J] . Liu Xing-Hai, Zhao Wen, Shen Zhong-Hua, Bioorganic and Medicinal Chemistry Letters . 2016,第15期

机译：新型手性1-（3-氯吡啶-2-基）-3-（三氟甲基）-1H-吡唑-4-羧酰胺衍生物的合成，杀线活性和对接研究
2. Synthesis and in vivo nematocidal evaluation of novel 3-(trifluoromethyl)-1H-pyrazole-4-carboxamide derivatives [J] . Zhao Wen, Xing Jiahua, Xu Tianming, Frontiers of chemical science and engine . 2017,第3期

机译：新型3-（三氟甲基）-1H-吡唑-4-羧酰胺衍生物的合成及体内杀线虫评价
3. Urea and thiourea derivatives of 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine: Synthesis, characterization, antimicrobial activity and docking studies [J] . Mannam Madhava Rao, Devineni Subba Rao, Pavuluri Chandra Mouli, Phosphorus, Sulfur, and Silicon and the Related Elements . 2019,第7a9期

机译：尿素和硫脲衍生物为3-（三氟甲基）-5,6,7,8-四氢[1,2,4]三唑[4,3-A]吡嗪：合成，表征，抗菌活性和对接研究
4. Synthesis and Fungicidal Activity of 4-Trifluoromethyl-2-thiazoline Derivatives [C] . Tatsuya Mori, Junichi Sato, Yuichi Matsuzaki, Proceedings of 4th international symposium on pesticides and environmental safety amp; 5th pan Pacific confernce on pesticide science amp; 8th international workshop on crop protection chemistry and regulatory harmonization . 2012

机译：4-三氟甲基-2-噻唑啉衍生物的合成及杀真菌活性
5. I. A1,3- strain enabled retention of chirality during Bis-cyclization of β-ketoamides: Asymmetric synthesis and bioactivity of salinosporamide a and derivatives II. Optimization of an Organic syntheses procedure: asymmetric nucleophile-catalyzed aldol-lactonization with aldehyde acids [D] . Nguyen, Henry 2010

机译：I. A1,3-菌株能够在β-酮基酰胺的双环化过程中保留手性：salinosporamide a和衍生物II的不对称合成和生物活性。有机合成程序的优化：醛酸不对称亲核催化醛醇内酯化
6. Synthesis and Antifungal Activity of N-(Substituted pyridinyl)-1-methyl(phenyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide Derivatives [O] . Zhibing Wu, Deyu Hu, Jiqing Kuang, 2012

机译：N-（取代的吡啶基）-1-甲基（苯基）-3-（三氟甲基）-1H-吡唑-4-羧酰胺衍生物的合成及抗真菌活性
7. Synthesis and Antifungal Activity of N-(Substituted pyridinyl)-1-methyl(phenyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide Derivatives [O] . Zhibing Wu, Deyu Hu, Jiqing Kuang, 2012

机译：N-（取代的吡啶基）-1-甲基（苯基）-3-（三氟甲基）-1H-吡唑-4-羧酰胺衍生物的合成及抗真菌活性

Synthesis, nematocidal activity and docking study of novel chiral 1-(3-chloropyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide derivatives

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