Synthesis and evaluation of substituted 4-(N-benzylamino)cinnamate esters as potential anti-cancer agents and HIV-1 integrase inhibitors

Faridoon; Edkins Adrienne L.; Isaacs Michelle; Mnkandhla Dumisani; Hoppe Heinrich C.; Kaye Perry T.

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Synthesis and evaluation of substituted 4-(N-benzylamino)cinnamate esters as potential anti-cancer agents and HIV-1 integrase inhibitors

机译：取代的4-（N-苄氨基）肉桂酸酯作为潜在的抗癌药和HIV-1整合酶抑制剂的合成与评价

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Encouraging selectivity and low micromolar activity against HeLa cervical carcinoma (IC50 >= 3.0 mu M) and the aggressive MDA-MB-231 triple negative breast carcinoma (IC50 >= 9.6 mu M) cell lines has been exhibited by a number of readily accessible 4-(N-benzylamino)cinnamate esters. The potential of the ligands as HIV-1 integrase inhibitors has also been examined. (C) 2016 Elsevier Ltd. All rights reserved.

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《Bioorganic and Medicinal Chemistry Letters》 |2016年第15期|共3页
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Faridoon; Edkins Adrienne L.; Isaacs Michelle; Mnkandhla Dumisani; Hoppe Heinrich C.; Kaye Perry T.;
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4-(N-Benzylamino)cinnamate esters; Anti-cancer agents; HIV-1 integrase inhibitors;

机译：4-（N-苄氨基）肉桂酸酯;抗癌剂;HIV-1整合酶抑制剂;

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1. Synthesis and evaluation of substituted 4-(N-benzylamino)cinnamate esters as potential anti-cancer agents and HIV-1 integrase inhibitors [J] . Faridoon, Edkins Adrienne L., Isaacs Michelle, Bioorganic and Medicinal Chemistry Letters . 2016,第15期

机译：取代的4-（N-苄氨基）肉桂酸酯作为潜在的抗癌药和HIV-1整合酶抑制剂的合成与评价
2. Synthesis of cinnamate estereAZT conjugates as potential dual-action HIV-1 integrase and reverse transcriptase inhibitors [J] . Temitope O. Olomola, Rosalyn Klein, Perry T. Kaye Tetrahedron . 2014,第49期

机译：肉桂酸酯eAZT偶联物的合成作为潜在的双重作用HIV-1整合酶和逆转录酶抑制剂
3. Synthesis of cinnamate estereAZT conjugates as potential dual-action HIV-1 integrase and reverse transcriptase inhibitors [J] . Temitope O. Olomola, Rosalyn Klein, Perry T. Kaye Tetrahedron . 2014,第49期

机译：肉桂酸酯eAZT偶联物的合成作为潜在的双重作用HIV-1整合酶和逆转录酶抑制剂
4. Synthesis and Conformational Analysis of a Natural Peptide Inhibitor of HIV-1 Integrase [C] . Marta De Zotti, Francesca Damato, Fernando Formaggio American Peptide Symposium . 2009

机译：HIV-1整合酶天然肽抑制剂的合成与构象分析
5. Design and synthesis of molecular probes to modulate cell membrane permeation: I. Design, synthesis, and biological evaluation of novel chicoric acid analogues as inhibitors of HIV-1 integrase. II. Design, synthesis, and biological evaluation of novel estradiol analogues targeting the membrane estrogen receptor. [D] . Charvat, Trevor Thomas. 2004

机译：设计和合成的分子探针，可调节细胞膜的渗透性：I.设计，合成和生物评价作为抗HIV-1整合酶抑制剂的新型菊苣酸类似物。二。针对膜雌激素受体的新型雌二醇类似物的设计，合成和生物学评估。
6. Single Agents with Designed Combination Chemotherapy Potential: Synthesis and Evaluation of Substituted Pyrimido45-bindoles as Receptor Tyrosine Kinase and Thymidylate Synthase Inhibitors and as Antitumor Agents [O] . Aleem Gangjee, Nilesh Zaware, Sudhir Raghavan, -1

机译：单药与设计联合化疗潜力：合成及取代的评价嘧啶并45-B吲哚作为受体酪氨酸激酶和胸苷酸合成酶抑制剂和抗肿瘤代理
7. Design, Synthesis and Evaluation of Novel N-Substituted-Benzoylamino-5-Ethyl-1,2,3,6-Tetrahydropyridines as Potential Anti-Cancer Agents [O] . Elizabeth D Henderson, Madhavi Gangapuram, Suresh Kumar VK Eyunni, 2019

机译：新型N-取代 - Benzoylamino -5-乙基-1,2,3,6-四氢吡啶作为潜在抗癌剂的设计，合成和评价

Synthesis and evaluation of substituted 4-(N-benzylamino)cinnamate esters as potential anti-cancer agents and HIV-1 integrase inhibitors

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