Leukemia Stem Cells Are Characterized By CLEC12A Expression and Chemotherapy Refractoriness That Can be Overcome By Targeting with Chimeric Antigen Receptor T Cells

Kenderian Saad S.; Ruella Marco; Shestova Olga; Klichinsky Michael; Kim Miriam Y.; Soderquist Craig; Bagg Adam; Singh Reshma; Richardson Celeste; Young Regina M.; June Carl H.; Gill Saar I.

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Leukemia Stem Cells Are Characterized By CLEC12A Expression and Chemotherapy Refractoriness That Can be Overcome By Targeting with Chimeric Antigen Receptor T Cells

机译：白血病干细胞的特征在于CLEC12A表达和化学疗法的难治性，可以通过靶向嵌合抗原受体T细胞来克服

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《Blood: The Journal of the American Society of Hematology》 |2016年第22期|共5页
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Kenderian Saad S.; Ruella Marco; Shestova Olga; Klichinsky Michael; Kim Miriam Y.; Soderquist Craig; Bagg Adam; Singh Reshma; Richardson Celeste; Young Regina M.; June Carl H.; Gill Saar I.;
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1. Leukemia Stem Cells Are Characterized By CLEC12A Expression and Chemotherapy Refractoriness That Can be Overcome By Targeting with Chimeric Antigen Receptor T Cells [J] . Kenderian Saad S., Ruella Marco, Shestova Olga, Blood: The Journal of the American Society of Hematology . 2016,第22期

机译：白血病干细胞的特征在于CLEC12A表达和化学疗法的难治性，可以通过靶向嵌合抗原受体T细胞来克服
2. Dual targeting of glioblastoma with chimeric antigen receptor-engineered natural killer cells overcomes heterogeneity of target antigen expression and enhances antitumor activity and survival [J] . Genssler Sabrina, Burger Michael C., Zhang Congcong, Oncoimmunology. . 2016,第4期

机译：嵌合抗原受体工程化的自然杀伤细胞对胶质母细胞瘤的双重靶向克服了靶抗原表达的异质性并增强了抗肿瘤活性和存活率
3. Immunotherapy with Autologous Anti-CD19 Chimeric Antigen Receptor T Cells Followed By Allogeneic Hematopoietic Stem Cell Transplantation Has Remarkably Improved Leukemia-Free Survival in Refractory/Relapsed B-Cell Acute Lymphoblastic Leukemia [J] . Zhao Yan-Li, Wu Tong, Liu De-Yan, Blood: The Journal of the American Society of Hematology . 2016,第22期

机译：自体抗CD19嵌合抗原受体T细胞的免疫治疗，随后进行异基因造血干细胞移植，显着改善了难治性/复发性B细胞急性淋巴细胞白血病中的无白血病生存率。
4. REMOVAL OF MYELOID CELLS FROM AUTOLOGOUS LEUKOCYTES USED FOR CHIMERIC ANTIGEN RECEPTOR (CAR) T CELL MANUFACTURING IMPROVES FINAL PRODUCT CONSISTENCY AND YIELDS [C] . David Stroncek, Daniel W. Lee, Marianna Sabatino, Scale-up and manufacturing of cell-based therapies V . 2017

机译：从用于嵌合抗原受体（CAR）T细胞制造的自体白细胞去除髓样细胞可改善最终产品的一致性和产量
5. CD30-Redirected Chimeric Antigen Receptor T Cells Target Embryonal Carcinoma via Antigen-Dependent and Fas/FasL Interactions [D] . Hong, Lee Kyung. 2018

机译：CD30-重定向的嵌合抗原受体T细胞通过抗原依赖性和FAS / FASL相互作用靶向胚胎癌
6. Dual targeting of glioblastoma with chimeric antigen receptor-engineered natural killer cells overcomes heterogeneity of target antigen expression and enhances antitumor activity and survival [O] . Sabrina Genßler, Michael C. Burger, Congcong Zhang, 2016

机译：用嵌合抗原受体工程化的自然杀伤细胞双重靶向胶质母细胞瘤克服了靶抗原表达的异质性并增强了抗肿瘤活性和存活率
7. Co-infusion of haplo-identical CD19-chimeric antigen receptor T cells and stem cells achieved full donor engraftment in refractory acute lymphoblastic leukemia [O] . Bo Cai, Mei Guo, Yao Wang, 2016

机译：单倍相同的CD19嵌合抗原受体T细胞和干细胞的共注入实现了难治性急性淋巴细胞白血病的完全供体植入

Leukemia Stem Cells Are Characterized By CLEC12A Expression and Chemotherapy Refractoriness That Can be Overcome By Targeting with Chimeric Antigen Receptor T Cells

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