• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Brain research >Effect of endurance training on seizure susceptibility, behavioral changes and neuronal damage after kainate-induced status epilepticus in spontaneously hypertensive rats
【24h】

Effect of endurance training on seizure susceptibility, behavioral changes and neuronal damage after kainate-induced status epilepticus in spontaneously hypertensive rats

机译：耐力训练对自发性高血压大鼠海藻酸盐诱发癫痫持续状态后癫痫发作敏感性，行为变化和神经元损伤的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The therapeutic efficacy of regular physical exercises in an animal model of epilepsy and depression comorbidity has been confirmed previously. In the present study, we examined the effects of endurance training on susceptibility to kainate (ICA)-induced status epilepticus (SE), behavioral changes and neuronal damage in spontaneously hypertensive rats (SHRs). Male SHRs were randomly divided into two groups. One group was exercised on a treadmill with submaximal loading for four weeks and the other group was sedentary. Immediately after the training period, SE was evoked in half of the sedentary and trained rats by KA, while the other half of the two groups received saline. Basal systolic (SP), diastolic (DP) and mean arterial pressure (MAP) of all rats were measured at the beginning and at the end of the training period. Anxiety, memory and depression-like behaviour were evaluated a month after SE. The release of 5-HT in the hippocampus was measured using a liquid scintillation method and neuronal damage was analyzed by hematoxylin and eosin staining. SP and MAP of exercised SHRs decreased in comparison with the initial values. The increased resistance of SHRs to KA-induced SE was accompanied by an elongated latent seizure-free period, improved object recognition memory and antidepressant effect after the training program. While the anticonvulsant and positive behavioral effects of endurance training were accompanied by an increase of 5-HT release in the hippocampus, it did not exert neuroprotective activity. Our results indicate that prior exercise is an effective means to attenuate KA-induced seizures and comorbid behavioral changes in a model of hypertension and epilepsy suggesting a potential influence of hippocampal 5-HT on a comorbid depression. However, this beneficial impact does not prevent the development of epilepsy and concomitant brain damage. (C) 2015 Elsevier B.V. All rights reserved.
机译：先前已经证实了常规体育锻炼在癫痫和抑郁合并症动物模型中的治疗功效。在本研究中，我们检查了耐力训练对自发性高血压大鼠（SHRs）对海藻酸盐（ICA）诱发的癫痫持续状态（SE）易感性，行为变化和神经元损害的影响。男性SHR随机分为两组。一组在最大负荷下的跑步机上运动四个星期，而另一组则久坐。训练期结束后，KA诱发了一半久坐和受训练的大鼠的SE，而两组的另一半则接受了盐水。在训练期的开始和结束时测量所有大鼠的基础收缩期（SP），舒张期（DP）和平均动脉压（MAP）。 SE后一个月评估焦虑，记忆和抑郁样行为。使用液体闪烁法测量5-HT在海马中的释放，并通过苏木精和曙红染色分析神经元损伤。与初始值相比，运动的SHR的SP和MAP降低。 SHR对KA诱导的SE的抵抗力增强，同时伴有更长的潜在无癫痫发作期，训练程序后改善的对象识别记忆和抗抑郁作用。虽然耐力训练的抗惊厥和积极的行为作用伴随着海马体内5-HT释放的增加，但它没有发挥神经保护作用。我们的结果表明，在高血压和癫痫模型中，先前的运动是减轻KA诱发的癫痫发作和合并症行为变化的有效手段，表明海马5-HT对合并症抑郁有潜在影响。但是，这种有益的影响并不能阻止癫痫的发展和随之而来的脑损伤。 （C）2015 Elsevier B.V.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号