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首页> 外文期刊>Brain research >Expression of ocular albinism 1 (OA1), 3, 4-dihydroxy- L-phenylalanine (DOPA) receptor, in both neuronal and non-neuronal organs
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Expression of ocular albinism 1 (OA1), 3, 4-dihydroxy- L-phenylalanine (DOPA) receptor, in both neuronal and non-neuronal organs

机译：眼白化病1（OA1），3，4-二羟基-L-苯丙氨酸（DOPA）受体在神经元和非神经元器官中的表达

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摘要

Oa1 is the casual gene for ocular albinism-1 in humans. The gene product OA1, alternatively designated as GPR143, belongs to G-protein coupled receptors. It has been reported that OA1 is a specific receptor for 3, 4-dihydroxy- L-phenylalanine (DOPA) in retinal pigmental epithelium where DOPA facilitates the pigmentation via OA1 stimulation. We have recently shown that OA1 mediates DOPA-induced depressor response in rat nucleus tractus solitarii. However, the distribution and function of OA1 in other regions are largely unlmown. We have generated OA1 knockout mice and examined OA1 expression in both neuronal and non-neuronal tissues by immunohistochemical analyses using anti-mouse OA1 monoclonal antibodies. In the telencephalon, OA1 was expressed in cerebral cortex and hippocampus. Predominant expression of OA1 was observed in the pyramidal neurons in these regions. OA1 was also expressed in habenular nucleus, hypothalamus, substantia nigra, and medulla oblongata. The expression of OA1 in the nucleus tiactus solitarii of medulla oblongata may support the reduction of blood pressure by the microinjection of DOPA into this region. Outside of the nervous system, OA1 was expressed in heart, lung, liver, kidney and spleen. Abundant expression was observed in the renal tubules and the splenic capsules. These peripheral regions are innervated by numerous sympathetic nerve endings. In addition, substantia nigra contains a large population of dopaminergic neurons. Thus, the immunohistochemical analyses suggest that OA1 may modulate the monoaminergic functions in both peripheral and central nervous systems. (C) 2015 Elsevier B.V. All rights reserved.
机译：Oa1是人类眼白化病1的偶然基因。基因产物OA1（也称为GPR143）属于G蛋白偶联受体。据报道，OA1是视网膜色素上皮中3，4-二羟基-L-苯丙氨酸（DOPA）的特异性受体，其中DOPA通过OA1刺激促进色素沉着。我们最近显示，OA1介导了大鼠孤核中多巴诱导的抑郁反应。但是，OA1在其他地区的分布和功能很大程度上未知。我们已经产生了OA1基因敲除小鼠，并使用抗小鼠OA1单克隆抗体通过免疫组织化学分析检查了神经元和非神经元组织中的OA1表达。在端脑中，OA1在大脑皮层和海马中表达。在这些区域的锥体神经元中观察到了OA1的主要表达。 OA1还表达于ha状核，下丘脑，黑质和延髓。 OA1在长延髓的椎间盘核中的表达可能支持通过将DOPA显微注射到该区域来降低血压。在神经系统之外，OA1在心脏，肺，肝脏，肾脏和脾脏中表达。在肾小管和脾脏胶囊中观察到大量表达。这些周围区域被许多交感神经末梢支配。另外，黑质含有大量的多巴胺能神经元。因此，免疫组织化学分析表明OA1可能调节周围和中枢神经系统中的单胺能功能。 （C）2015 Elsevier B.V.保留所有权利。

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