Synthesis,Characterization,and Folding Behavior of beta-Amino Acid Derived Polyisocyanides

Sander J.Wezenberg; Gerald A.Metselaar; Alan E.Rowan; Jeroen J.L.M.Cornelissen; Dieter Seebach

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Synthesis,Characterization,and Folding Behavior of beta-Amino Acid Derived Polyisocyanides

机译：β-氨基酸衍生的多异氰酸酯的合成，表征和折叠行为

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Helical polymers of isocya-nopeptides derived from beta-amino acids have been synthesized and their architectures have been studied in detail.Similar to their alpha-amino acid analogues,the helical conformation in these macromolecules is stabilized by internal hydrogen-bonding arrays along the polymeric backbone.Unexpectedly,the flexibility of the beta-peptide side arms results in a rearrangement of the initial macromolecular architecture,leading to a more stable helical structure possessing a better defined hydrogen-bonding pattern,as was concluded from IR and temperature-dependent circular dichroism studies.Based on these results we propose a dynamic helical model for the beta-amino acid derived polyisocyanopeptides;this model is in contrast to the kinetically stable helical macromolecules that are formed upon polymerization of alpha-amino acid based isocyanopeptides.

机译：已经合成了衍生自β-氨基酸的异邻肽的螺旋聚合物，并对其结构进行了详细研究。与它们的α-氨基酸类似物类似，这些大分子中的螺旋构象通过沿聚合物内部的氢键阵列得以稳定出乎意料的是，由IR和温度依赖性圆二色性得出的结论是，β肽侧臂的柔韧性导致了初始大分子结构的重排，从而导致了更稳定的螺旋结构，具有更清晰的氢键结合模式。基于这些结果，我们提出了β-氨基酸衍生的聚异氰肽的动态螺旋模型;该模型与基于α-氨基酸的异氰肽聚合形成的动力学稳定的螺旋大分子相反。

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《Chemistry: A European journal》 |2006年第10期|共9页
作者
Sander J.Wezenberg; Gerald A.Metselaar; Alan E.Rowan; Jeroen J.L.M.Cornelissen; Dieter Seebach;
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正文语种 eng
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beta peptides; conformation analysis; helical structures; hydrogen bonds; polyisocyanides;

机译：β肽;构象分析;螺旋结构;氢键;聚异氰酸酯;

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Synthesis,Characterization,and Folding Behavior of beta-Amino Acid Derived Polyisocyanides

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