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首页> 外文期刊>Chemistry: A European journal >Free-amine-directed alkenylation of C(sp~2)-H and cycloamination by palladium catalysis
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Free-amine-directed alkenylation of C(sp~2)-H and cycloamination by palladium catalysis

机译：C（sp〜2）-H的游离胺指导的烯基化和钯催化的环胺化

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摘要

A new protocol for the palladium-catalyzed free-amine-directed alkenylation of C(sp~2)-H bonds and cycloamination is described. Substituted biaryl-2-amines react with various alkenes, including electron-deficient alkenes, aryl alkenes and alkyl alkenes, to give the corresponding phenanthridines with exclusive regioselectivity. The use of α-branched styrenes leads to the formation of tricyclic compounds with a seven-membered amine ring. The method operates through a free-amine-directed alkenylation and a subsequent hydroamination cyclization reaction. Seven-membered cycloamination: A new protocol for the palladium-catalyzed free-amine-directed alkenylation of C(sp~2)-H bonds and subsequent cycloamination is described (see scheme). Substituted biaryl-2-amines react with various alkenes to give the corresponding phenanthridines with exclusive regioselectivity. The use of α-branched styrenes leads to the formation of tricyclic compounds with a seven-membered amine ring.
机译：描述了一种新的协议，用于钯催化的C（sp〜2）-H键和胺的环胺化反应。取代的联芳基-2-胺与各种烯烃（包括缺电子的烯烃，芳基烯烃和烷基烯烃）反应，得到具有排他区域选择性的相应菲啶。 α-支链苯乙烯的使用导致形成具有七元胺环的三环化合物。该方法通过游离胺定向的烯基化和随后的加氢胺化环化反应来进行。七元环胺化：描述了一种新的方案，用于钯催化C（sp〜2）-H键的游离胺定向的烯基化反应和随后的环胺化（参见方案）。取代的联芳基-2-胺与各种烯烃反应，以排他性区域选择性得到相应的菲啶。 α-支链苯乙烯的使用导致形成具有七元胺环的三环化合物。

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