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首页> 外文期刊>Chemistry: A European journal >PH-Dependent release of doxorubicin from fast photo-cross-linkable polymersomes based on benzophenone units
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PH-Dependent release of doxorubicin from fast photo-cross-linkable polymersomes based on benzophenone units

机译：PH依赖于基于二苯甲酮单元的快速光可交联聚合物囊泡释放阿霉素

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摘要

A new class of pH-sensitive and photo-crosslinked polymersomes based on 2-hydroxy-4-(methacryloyloxy) benzophenone(BMA) as an effective photo crosslinker requiring short UV irradiation times was presented. The cross-linked polymersomes based on CP3, CP5, and CP10 reveal the desired stability over the whole pH range. Polymersomes based on CP10 show the fastest cross-linking, and in this case, five minutes of UV irradiation were enough to keep the vesicular shape of the polymersomes upon their acidification. The strong influence of the crosslinking time on the stability and swelling power of the crosslinked polymersomes is found. Under storage conditions of pH 7.4 at 4°C, Dox showed good retention behavior within polymersomes cross-linked for 20 min. At the physiological temperature, Dox started to release from the polymersomes with different profiles depending on the cross-linking time and the pH of the release medium.
机译：提出了一种新型的基于2-羟基-4-（甲基丙烯酰氧基）二苯甲酮（BMA）的pH敏感和光交联的聚合物囊泡，它是一种需要短紫外线照射时间的有效光交联剂。基于CP3，CP5和CP10的交联聚合物囊泡在整个pH范围内显示出所需的稳定性。基于CP10的聚合物囊泡显示最快的交联，在这种情况下，五分钟的紫外线照射足以在聚合物囊泡酸化后保持其囊泡形状。发现交联时间对交联聚合物囊泡的稳定性和溶胀能力的强烈影响。在4°C下pH 7.4的存储条件下，Dox在交联的聚合物小体中显示出良好的保留行为，持续20分钟。在生理温度下，取决于交联时间和释放介质的pH，Dox开始以不同的形态从聚合物囊泡中释放出来。

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