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首页> 外文期刊>Chemistry: A European journal >Room-Temperature Hydrohydrazination of Terminal Alkynes Catalyzed by Saturated Abnormal N-Heterocyclic Carbene–Gold(I) Complexes
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Room-Temperature Hydrohydrazination of Terminal Alkynes Catalyzed by Saturated Abnormal N-Heterocyclic Carbene–Gold(I) Complexes

机译：饱和异常N-杂环卡宾-金（I）配合物催化末端炔烃的室温氢化肼化

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摘要

A number of saturated abnormal N-heterocyclic carbene (NHC) complexes of gold, in combination with KBAr_4~F as activator, were successfully applied in the chemoselective addition of hydrazine to alkynes. The reaction proceeds even at room temperature, which was not possible to date with gold catalysts. The reaction can be applied to a number of substituted arylalkynes. With alkylalkynes the yields are low. The saturated abnormal NHC ligands are resistant to isomerization to the saturated normal NHC coordination mode under basic reaction conditions. Under acidic conditions, a simple protonation at the nitrogen atom not neighboring the carbene center was observed and unambiguously characterized by an X-ray crystal-structure analysis. Computational studies confirm that such an isomerization would be highly exothermic, the observed kinetic stability probably results from the need to shift two protons in such a process.
机译：结合KBAr_4〜F作为活化剂，成功地将许多饱和的N型杂环碳烯（NHC）金配合物成功地用于肼的化学选择性加成。该反应甚至在室温下也可以进行，而这在金催化剂下是不可能的。该反应可以应用于许多取代的芳基炔烃。使用烷基炔烃，收率低。在碱性反应条件下，饱和的异常NHC配体可抵抗异构化为饱和的正常NHC配位模式。在酸性条件下，观察到在不与卡宾中心相邻的氮原子上的简单质子化，并通过X射线晶体结构分析明确地表征。计算研究证实，这种异构化反应会放热，观察到的动力学稳定性可能是由于在此过程中需要转移两个质子所致。

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