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首页> 外文期刊>Chemistry: A European journal >Drug Encapsulation and Release by Mesoporous Silica Nanoparticles: The Effect of Surface Functional Groups
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Drug Encapsulation and Release by Mesoporous Silica Nanoparticles: The Effect of Surface Functional Groups

机译：介孔二氧化硅纳米粒子的药物封装和释放：表面官能团的影响

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Mesoporous silica nanoparticles (MSNPs) have been widely used as drug carriers for stimuli-responsive drug delivery. Herein, a catalysis screening technique was adopted for analyzing the effects of chain length, terminal group, and density of disulfide-appended functional ligands on the surface of MSNPs on drug-loading capacity and glutathione-triggered drug-release kinetics. The ligand with an intermediate length (5 carbon atoms) and a bulky terminal group (cyclohexyl) that complexes with theb-cyclodextrin ring showed the highest drug loading capacity as well as good release kinetics. In addition, decreasing the surface coverage of the functional ligands led to an enhancement in drug release. In vitro drug-delivery experiments on a melanoma cell line (B16-F10) by using the functionalized MSNPs further supported the conclusion. The results obtained may serve as a general guide for developing more effective MSNP systems for drug delivery.
机译：介孔二氧化硅纳米粒子（MSNPs）已被广泛用作刺激性药物传递的药物载体。在本文中，采用催化筛选技术来分析MSNPs表面的链长，端基和二硫键附加的功能性配体的密度对载药量和谷胱甘肽触发的药物释放动力学的影响。具有中间长度（5个碳原子）和与b-环糊精环络合的庞大末端基团（环己基）的配体显示出最高的药物负载能力以及良好的释放动力学。另外，减少功能性配体的表面覆盖导致药物释放的增加。通过使用功能化的MSNP在黑色素瘤细胞系（B16-F10）上进行体外药物递送实验，进一步支持了该结论。获得的结果可作为开发更有效的MSNP药物输送系统的一般指南。

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