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首页> 外文期刊>Chemistry: A European journal >Size, Charge, and Stability of Fully Serine-Based Catanionic Vesicles: Towards Versatile Biocompatible Nanocarriers
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Size, Charge, and Stability of Fully Serine-Based Catanionic Vesicles: Towards Versatile Biocompatible Nanocarriers

机译：大小，电荷和完全基于丝氨酸的阳离子囊泡的稳定性：向多功能生物相容性纳米载体。

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摘要

Vesicles based on mixed cationic and anionic surfactants (catanionic vesicles) offer a number of advantageous colloidal features over conventional lipid-based vesicles, namely spontaneity in formation, long-term stability, and easy modulation of size and charge. If biocompatibility is added through rational design of the chemical components, the potential for biorelated applications further emerges. Here, we report for the first time on two catanionic vesicle systems in which both ionic amphiphiles are derivatized from the same amino acid-serine-with the goal of enhancing aggregate biocompatibility. Phase behavior maps for a mixture with chain length symmetry, 12Ser/12-12Ser, and another with asymmetry, 16Ser/8-8Ser, are presented, for which regions of vesicles, micelles, and coexisting aggregates are identified. For the asymmetric mixture, detailed phase behavior and microstructure characterization have been carried out based on surface tension, light microscopy, cryo-SEM, cryo-TEM, and dynamic light scattering analysis. Vesicles are found with tunable mean size, pH, and zeta potential. Changes in aggregate shape with varying composition and the effect of preparation methods and aging on vesicle features and stability have been investigated in detail. The results are discussed in the light of self-assembly models and related catanionic systems reported before. A versatile system of robust vesicles is thus presented for potential applications.
机译：与常规的基于脂质的囊泡相比，基于混合的阳离子和阴离子表面活性剂的囊泡（催化性囊泡）具有许多有利的胶体特征，即自发形成，长期稳定性以及易于调节尺寸和电荷。如果通过合理设计化学成分增加生物相容性，则生物相关应用的潜力将进一步显现。在这里，我们首次报道了两个阳离子小泡系统，其中两个离子两亲物均从相同的氨基酸丝氨酸衍生而来，目的是提高聚集生物相容性。给出了具有链长对称性（12Ser / 12-12Ser）和另一种具有不对称性的混合物（16Ser / 8-8Ser）的相行为图，其中鉴定了囊泡，胶束和共存聚集体的区域。对于不对称混合物，已经基于表面张力，光学显微镜，低温-SEM，低温-TEM和动态光散射分析进行了详细的相行为和微观结构表征。发现囊泡具有可调的平均大小，pH和ζ电位。详细研究了聚集体形状随组成的变化以及制备方法的影响以及老化对囊泡特征和稳定性的影响。根据之前报道的自组装模型和相关的阳离子体系对结果进行了讨论。因此，提出了一种健壮囊泡的通用系统，用于潜在的应用。

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