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首页> 外文期刊>Chemistry: A European journal >Surface Enhanced Raman Scattering and Gated Materials for Sensing Applications: The Ultrasensitive Detection of Mycoplasma and Cocaine
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Surface Enhanced Raman Scattering and Gated Materials for Sensing Applications: The Ultrasensitive Detection of Mycoplasma and Cocaine

机译：用于传感应用的表面增强拉曼散射和门控材料：支原体和可卡因的超灵敏检测

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摘要

We present herein a novel combination of gated mesoporous silica nanoparticles (MSNs) and surface-enhanced Raman scattering (SERS) for sensing applications. As a proof-of-concept, we show the design of a system comprising MSNs loaded with crystal violet (CV), a molecule with high Raman cross section acting as SERS reporter, and capped with either a suitable DNA sequence for the detection of Mycoplasma genomic DNA or with an aptamer that selectively coordinates cocaine. In both cases the presence of the corresponding target analyte in solution (i.e., genomic DNA or cocaine) resulted in the release of CV. CV delivery was detected by SERS upon adsorption on gold nanotriangles (AuNTs), which display an efficient electromagnetic field enhancement and a high colloidal stability. By using this novel procedure a limit of detection of at least 30 copies DNA per mu L was determined for the detection of Mycoplasma genomic DNA, whereas cocaine was detected at concentrations as low as 10 nm.
机译：我们在这里提出传感应用的门控介孔二氧化硅纳米粒子（MSNs）和表面增强拉曼散射（SERS）的新型组合。作为概念验证，我们展示了一个系统的设计，该系统包括装载有结晶紫（CV），具有高拉曼横截面的分子的SSN，充当SERS报告分子，并用合适的DNA序列加帽以检测支原体基因组DNA或具有适度可卡因的适体。在两种情况下，溶液（即基因组DNA或可卡因）中相应目标分析物的存在均导致CV的释放。 SERS吸附在金纳米三角形（AuNT）上后，通过SERS检测到CV传递，该纳米三角形显示出有效的电磁场增强和高胶体稳定性。通过使用这种新颖的方法，确定了每μL至少30拷贝DNA的检测限，以检测支原体基因组DNA，而可卡因的检测浓度低至10 nm。

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