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首页> 外文期刊>American Journal of Physiology >Effects of Boswellia serrata in mouse models of chemically induced colitis.
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Effects of Boswellia serrata in mouse models of chemically induced colitis.

机译：乳香对化学诱导性结肠炎的小鼠模型的影响。

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Extracts from Boswellia serrata have been reported to have anti-inflammatory activity, primarily via boswellic acid-mediated inhibition of leukotriene synthesis. In three small clinical trials, boswellia was shown to improve symptoms of ulcerative colitis and Crohn's disease, and because of its alleged safety, boswellia was considered superior over mesalazine in terms of a benefit-risk evaluation. The goal of this study was to evaluate the effectiveness of boswellia extracts in controlled settings of dextran sulfate- or trinitrobenzene sulfonic acid-induced colitis in mice. Our results suggest that boswellia is ineffective in ameliorating colitis in these models. Moreover, individual boswellic acids were demonstrated to increase the basal and IL-1beta-stimulated NF-kappaB activity in intestinal epithelial cells in vitro as well as reverse proliferative effects of IL-1beta. We also observed hepatotoxic effect of boswellia with pronounced hepatomegaly and steatosis. Hepatotoxity and increased lipid accumulation in response to boswellia were further confirmed in vitro in HepG2 cells with fluorescent Nile red binding/resazurin reduction assay and by confocal microscopy. Microarray analyses of hepatic gene expression demonstrated dysregulation of a number of genes, including a large group of lipid metabolism-related genes, and detoxifying enzymes, a response consistent with that to hepatotoxic xenobiotics. In summary, boswellia does not ameliorate symptoms of colitis in chemically induced murine models and, in higher doses, may become hepatotoxic. Potential implications of prolonged and uncontrolled intake of boswellia as an herbal supplement in inflammatory bowel disease and other inflammatory conditions should be considered in future clinical trials with this botanical.
机译：据报道，来自乳香锯缘青蟹的提取物具有抗炎活性，主要是通过乳香酸介导的白三烯合成的抑制作用。在三项小型临床试验中，乳香显示可改善溃疡性结肠炎和克罗恩氏病的症状，并且由于其所谓的安全性，在有益风险评估方面，乳香被认为优于美沙拉嗪。这项研究的目的是评估乳香提取物在硫酸右旋糖酐或三硝基苯磺酸诱导的小鼠结肠炎的控制环境中的有效性。我们的结果表明，在这些模型中，乳香不能有效改善结肠炎。此外，已证明单个乳香酸在体外可增加肠上皮细胞中基础和IL-1β刺激的NF-κB活性以及IL-1beta的逆向增殖作用。我们还观察到了乳香的肝毒性作用，并伴有明显的肝肿大和脂肪变性。通过荧光尼罗红结合/刃天青还原减少试验和共聚焦显微镜，进一步证实了HepG2细胞在体外对乳香的肝毒性和脂质积累的增加。肝基因表达的微阵列分析表明，许多基因表达失调，包括一大批与脂质代谢相关的基因和解毒酶，这与对肝毒性异种生物的反应一致。总而言之，乳香不能在化学诱导的鼠模型中改善结肠炎的症状，大剂量服用可能会引起肝毒性。在这种植物药的未来临床试验中，应考虑长期和不受控制地摄入乳香作为草药补充剂，可能会引起炎症性肠病和其他炎症。

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