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首页> 外文期刊>American Journal of Physiology >Mitochondrial ATP-sensitive potassium channels and mitochondrial protein kinase C: sometimes it's good to have a close neighbor
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Mitochondrial ATP-sensitive potassium channels and mitochondrial protein kinase C: sometimes it's good to have a close neighbor

机译：线粒体ATP敏感性钾通道和线粒体蛋白激酶C：有时最好有一个近邻

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the fine study by Jiang . (8) in this issue of the American Journal of Physiology Heart and Circulatory Physiology is an important milestone in the ongoing studies on the role of the mitochondrial ATP-sensitive K~+ (mitoK_ATP) channels in myo-cardial ischemia. It is not particularly surprising that this channel exists in human cardiac myocytes, because most proteins are highly conserved in mitochondria despite the fact that many of these proteins, including K_ATP, are encoded from nuclear genes. What is important is finding the presence of an inward rectifying K~+ channel (Kir)6.2 reactive protein and its regulation by a PKC, both located within the inner mitochondrial membrane. Now, looking on this as a pharmacologist, this is a more satisfying solution than the translocation of a cyto-plasmic PKC isoform that is more typically seen for activation of cell surface receptors. Several excellent studies (5, 11) have shown the importance of PKC in preconditioning, although these studies tended to focus on cytoplasmic isoforms
机译：江泽民的优良作风。 （8）在本期《美国生理学杂志》上，《心脏与循环生理学》是正在进行的关于线粒体ATP敏感K〜+（mitoK_ATP）通道在心肌缺血中作用的重要里程碑。该通道存在于人心肌细胞中并不奇怪，因为尽管许多蛋白质（包括K_ATP）是从核基因编码的事实，但大多数蛋白质在线粒体中都是高度保守的。重要的是找到位于线粒体内膜内的向内整流的K〜+通道（Kir）6.2反应蛋白的存在及其对PKC的调节。现在，以药理学家的身份来看，这是比细胞质PKC同工型易位更令人满意的解决方案，后者在细胞表面受体的激活中更为常见。几项出色的研究（5、11）显示了PKC在预处理中的重要性，尽管这些研究往往侧重于细胞质亚型

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