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首页> 外文期刊>American Journal of Physiology >Hepatic beta-oxidation and carnitine palmitoyltransferase I in neonatal pigs after dietary treatments of clofibric acid, isoproterenol, and medium-chain triglycerides.
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Hepatic beta-oxidation and carnitine palmitoyltransferase I in neonatal pigs after dietary treatments of clofibric acid, isoproterenol, and medium-chain triglycerides.

机译：饮食中使用氯纤酸，异丙肾上腺素和中链甘油三酸酯饮食治疗后，新生猪的肝β-氧化和肉碱棕榈酰转移酶I。

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摘要

A suckling piglet model was used to study nutritional and pharmacologic means of stimulating hepatic fatty acid beta-oxidation. Newborn pigs were fed milk diets containing either long- or medium-chain triglycerides (LCT or MCT). The long-chain control diet was supplemented further with clofibric acid (0.5%) or isoproterenol (40 ppm), and growth was monitored for 10-12 days. Clofibrate increased rates of hepatic peroxisomal and mitochondrial beta-oxidation of [1-(14)C]-palmitate by 60 and 186%, respectively. Furthermore, malonyl-CoA sensitive carnitine palmitoyltransferase (CPT I) activity increased 64% (P < 0.05) in pigs receiving clofibrate. Increased CPT I activity was not congruent with changes in message, as elevated abundance of CPT I mRNA was not detected (P = 0.16) when assessed by qRT-PCR. Neither rates of beta-oxidation nor CPT activities were affected by dietary MCT or by isoproterenol treatment (P > 0.1). Collectively, these findings indicate that clofibrate effectively induced hepatic CPT activity concomitant with increased fatty acid beta-oxidation.
机译：使用乳猪模型研究刺激肝脂肪酸β-氧化的营养和药理学方法。给新生猪饲喂含有长链或中链甘油三酸酯（LCT或MCT）的牛奶。长链对照饮食中还补充了氯纤维酸（0.5％）或异丙肾上腺素（40 ppm），并监测了10-12天的生长。氯贝贝特可使[1-（14）C]-棕榈酸酯的肝过氧化物酶体和线粒体β-氧化速率分别增加60％和186％。此外，丙二酰辅酶A敏感的肉碱棕榈酰转移酶（CPT I）活性在接受氯贝贝特的猪中增加了64％（P <0.05）。 CPT I活性的增加与信息的变化不符，因为通过qRT-PCR评估时未检测到CPT I mRNA的丰度升高（P = 0.16）。饮食MCT或异丙肾上腺素治疗均不影响β-氧化速率和CPT活性（P> 0.1）。总体而言，这些发现表明，氯贝贝特有效地诱导了肝脏CPT活性，同时增加了脂肪酸β-氧化。

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