• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Evidence for epithelial-mesenchymal transitions in adult liver cells.
【24h】

Evidence for epithelial-mesenchymal transitions in adult liver cells.

机译：成年肝细胞上皮-间质转化的证据。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Both myofibroblastic hepatic stellate cells (HSC) and hepatic epithelial progenitors accumulate in damaged livers. In some injured organs, the ability to distinguish between fibroblastic and epithelial cells is sometimes difficult because cells undergo epithelial-mesenchymal transitions (EMT). During EMT, cells coexpress epithelial and mesenchymal cell markers. To determine whether EMT occurs in adult liver cells, we analyzed the expression profile of primary HSC, two HSC lines, and hepatic epithelial progenitors. As expected, all HSC expressed HSC markers. Surprisingly, these markers were also expressed by epithelial progenitors. In addition, one HSC line expressed typical epithelial progenitor mRNAs, and these epithelial markers were inducible in the second HSC line. In normal and damaged livers, small ductular-type cells stained positive for an HSC marker. In conclusion, HSC and hepatic epithelial progenitors both coexpress epithelial and mesenchymal markers, providing evidence that EMT occurs in adult liver cells.
机译：肌纤维母细胞肝星状细胞（HSC）和肝上皮祖细胞均在受损的肝脏中积累。在某些受伤的器官中，有时很难区分成纤维细胞和上皮细胞，因为细胞会经历上皮-间质转化（EMT）。在EMT期间，细胞共表达上皮和间充质细胞标志物。为了确定成人肝细胞中是否发生EMT，我们分析了原代HSC，两个HSC系和肝上皮祖细胞的表达情况。如预期的那样，所有HSC均表达了HSC标记。出乎意料的是，这些标记物也由上皮祖细胞表达。此外，一个HSC系表达典型的上皮祖细胞mRNA，并且这些上皮标记物可在第二个HSC系中诱导。在正常和受损的肝脏中，小的导管型细胞的HSC标记染色呈阳性。总之，HSC和肝上皮祖细胞均共同表达上皮和间充质标志物，提供了EMT发生在成年肝细胞中的证据。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号