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首页> 外文期刊>American Journal of Physiology >Progressive diabetic nephropathy in the Ren-2 rat
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Progressive diabetic nephropathy in the Ren-2 rat

机译：Ren-2大鼠的进行性糖尿病肾病

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To the Editor: We thank Hartner and colleagues (1) for their interest in the studies by our group and their efforts to replicate our findings. As detailed in their discussion, there are several aspects regarding their experimental design that may have contributed to the observed differences between their findings and ours. In addition and not mentioned by the authors is the possibility that their animals developed malignant hypertension, thereby confounding the interpretability of their study findings. We note both the substantial decline in mean arterial pressure (MAP) between weeks 5 and 20 that suggest the development of heart failure and histopathological findings in Fig. 5 that are reminiscent of myointimal proliferation
机译：致编辑：感谢Hartner及其同事（1）对我们小组的研究感兴趣以及他们为复制我们的发现所做的努力。正如他们讨论中所详述的，关于他们的实验设计，有几个方面可能导致了他们与我们的发现之间观察到的差异。此外，作者没有提及的是，他们的动物患上恶性高血压的可能性，从而混淆了他们研究结果的可解释性。我们注意到第5周到第20周之间平均动脉压（MAP）的显着下降表明心力衰竭的发展，而图5中的组织病理学发现让人想起了肌内膜增生

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