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首页> 外文期刊>American Journal of Physiology >The effects of salt-induced hypertension on alpha1-adrenoreceptor expression and cardiovascular physiology in the rainbow trout (Oncorhynchus mykiss).
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The effects of salt-induced hypertension on alpha1-adrenoreceptor expression and cardiovascular physiology in the rainbow trout (Oncorhynchus mykiss).

机译：盐诱导的高血压对虹鳟鱼（Oncorhynchus mykiss）α1-肾上腺素受体表达和心血管生理的影响。

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摘要

Experiments were conducted on rainbow trout to determine the impact of dietary salt on arterial blood pressure. After 4-6 wk, fish fed a salt-enriched diet exhibited a 37% elevation of dorsal aortic pressure (from 23.8 +/- 1.2 to 32.6 +/- 1.4 mmHg) and an 18% increase in ventral aortic pressure (from 33.0 +/- 1.5 to 38.9 +/- 1.3 mmHg). The hypertension presumably reflected the increase in cardiac output (from 31.0 +/- 0.8 to 36.4 +/- 2.2 ml.min(-1).kg(-1)) because systemic and branchial resistances were statistically unaltered by salt feeding. The chronic hypertension was associated with a decrease in the pressor responses of the systemic vasculature to catecholamines and hypercapnia in the salt-fed fish. The reduction in alpha-adrenergic responsiveness of the systemic vasculature is consistent with desensitization or loss of functional alpha-adrenoceptors (alpha-ARs). In support of this idea, the salt-fed fish exhibited significantly decreased levels of alpha(1D)-AR mRNA in the dorsal aorta and the afferent (ABA) and efferent branchial arteries (EBA). In contrast, however, the results obtained from norepinephrine dose-response curves for EBA and ABA vascular rings in vitro did not provide evidence for loss of function of branchial artery alpha(1)-ARs in the salt-fed fish. Indeed, the EC(50) for the EBA norepinephrine dose-response curve was significantly reduced (from 3.75 x 10(-7) to 2.12 x 10(-7) M) in the salt-fed fish, indicating an increase in the binding affinity of the alpha(1)-ARs.
机译：在虹鳟鱼上进行了实验，以确定饮食盐对动脉血压的影响。 4-6周后，喂食高盐饮食的鱼的背主动脉压升高了37％（从23.8 +/- 1.2升高到32.6 +/- 1.4 mmHg），腹主动脉压升高了18％（从33.0 + /-1.5至38.9 +/- 1.3毫米汞柱）。高血压可能反映了心排血量的增加（从31.0 +/- 0.8增至36.4 +/- 2.2 ml.min（-1）.kg（-1）），因为盐饲喂对全身和分支阻力均无统计学影响。慢性高血压与食盐鱼类中全身脉管系统对儿茶酚胺和高碳酸血症的升压反应降低有关。全身脉管系统的α-肾上腺素反应性的降低与功能性α-肾上腺素受体（α-ARs）的脱敏或丧失一致。为支持这一观点，用盐喂养的鱼在背主动脉以及传入（ABA）和传出分支动脉（EBA）中表现出明显降低的alpha（1D）-AR mRNA水平。然而，相比之下，从EBA和ABA血管环的去甲肾上腺素剂量-反应曲线获得的结果没有提供盐食用鱼中分支动脉α（1）-ARs功能丧失的证据。实际上，盐腌鱼中EBA去甲肾上腺素剂量-反应曲线的EC（50）显着降低（从3.75 x 10（-7）降至2.12 x 10（-7）M），表明结合增加alpha（1）-AR的亲和力。

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