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首页> 外文期刊>American Journal of Physiology >Oxytocin knockout mice demonstrate enhanced intake of sweet and nonsweet carbohydrate solutions.
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Oxytocin knockout mice demonstrate enhanced intake of sweet and nonsweet carbohydrate solutions.

机译：催产素基因敲除小鼠证明增加了甜和不甜碳水化合物溶液的摄入。

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Oxytocin knockout (OT KO) mice display enhanced intake of nutritive and nonnutritive sweet solutions (i.e., sucrose and saccharin) compared with wild-type (WT) mice of the same C57BL/6 background strain. The present study further investigated the differential behavioral response of OT KO and WT mice to sucrose solutions and also examined intake preferences of OT KO and WT mice for palatable but nonsweet isocaloric solutions of carbohydrate and fat. A progressive ratio operant licking procedure demonstrated that OT KO and WT mice display a similar motivational drive to consume 10% sucrose. A series of two-bottle intake tests revealed that OT KO mice consume significantly larger amounts of both sweet and nonsweet carbohydrate solutions (i.e., sucrose, Polycose, and cornstarch) compared with WT cohorts. Intake pattern analyses revealed that OT KO mice overconsume carbohydrate solutions by initiating more drinking bouts compared with WT mice; bout sizes did not differ between the genotypes. In contrast, OTKO and WT mice did not differ in their intake of Intralipid, a palatable soybean oil emulsion. These findings indicate that the absence of OT in mice does not affect their appetitive drive to consume palatable sucrose solutions. Instead, the absence of OT may increase daily intake of palatable sweet and nonsweet solutions of carbohydrate (but not fat) by selectively blunting or masking processes that contribute to postingestive satiety.
机译：与相同C57BL / 6背景菌株的野生型（WT）小鼠相比，催产素基因敲除（OT KO）小鼠的营养和非营养甜味溶液（即蔗糖和糖精）摄入量增加。本研究进一步研究了OT KO和WT小鼠对蔗糖溶液的不同行为反应，并且还研究了OT KO和WT小鼠对可口但不甜的碳水化合物和脂肪等温溶液的摄入偏好。渐进式比例操作性舔procedure程序表明OT KO和WT小鼠表现出相似的动机消耗10％蔗糖。一系列的两瓶摄入测试显示，与WT组相比，OT KO小鼠消耗的甜味和非甜味碳水化合物溶液（即蔗糖，Polycose和玉米淀粉）明显多得多。摄入模式分析显示，与WT小鼠相比，OT KO小鼠通过发起更多的饮水而过度消耗碳水化合物溶液。轮回大小在基因型之间没有差异。相比之下，OTKO和WT小鼠在摄入Intralipid（一种可口的大豆油乳剂）中的摄取没有差异。这些发现表明，小鼠中不存在OT不会影响其食用可口蔗糖溶液的食欲。相反，不存在OT可能会通过选择性地钝化或掩盖有助于产生饱腹感的过程来增加可口的甜味和不甜味的碳水化合物（而不是脂肪）溶液的每日摄入量。

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