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首页> 外文期刊>American Journal of Physiology >Leg flow-mediated arterial dilation in elderly patients with heart failure and normal left ventricular ejection fraction.
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Leg flow-mediated arterial dilation in elderly patients with heart failure and normal left ventricular ejection fraction.

机译：患有心力衰竭且左心室射血分数正常的老年患者的腿流介导的动脉扩张。

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摘要

BACKGROUND: flow-mediated arterial dilation (FMAD), an indicator of endothelial function, is reduced in patients with heart failure and reduced left ventricular ejection fraction (HFREF). Many elderly patients with heart failure exhibit a normal left ventricular ejection fraction (HFNEF). It is unknown whether FMAD is severely reduced in the elderly with HFNEF. METHODS AND RESULTS: 30 participants >60 yr of age, 11 healthy, 9 with HFNEF, and 10 with HFREF, underwent a cardiovascular magnetic resonance (CMR) assessment of FMAD in the superficial femoral artery followed within 48 h by symptom-limited exercise with expired gas analysis. Elderly patients with HFREF and HFNEF had severely reduced peak oxygen consumption (Vo(2 peak); 12 +/- 2 and 13 +/- 1 ml.kg(-1).min(-1), respectively) vs. their healthy age-matched contemporaries (20 +/- 3 ml.kg(-1).min(-1)). FMAD was 3.8 +/- 1.3% (0.85 +/- 0.22 mm(2)) in patients with HFREF; it was 12.1 +/- 3.6% (3.1 +/- 1.2 mm(2)) and 13.7 +/- 5.9% (3.9 +/- 1.7 mm(2)), respectively, in patients with HFNEF and age-matched healthy older individuals. After adjustment for age and gender, the association of FMAD with Vo(2) was high in healthy and HFREF subjects (P = 0.05 and 0.02, respectively) but less so in HFNEF participants (P = 0.58). CONCLUSIONS: elderly patients with HFNEF do not exhibit marked reduction in leg FMAD. These data suggest that mechanisms other than impaired femoral arterial endothelial function contribute to the severe exercise intolerance experienced by these individuals.
机译：背景：心力衰竭患者左心室射血分数（HFREF）降低，血流介导的动脉扩张（FMAD）是内皮功能的指标。许多老年心衰患者表现出正常的左心室射血分数（HFNEF）。尚不清楚HFNEF老年人中FMAD是否会严重降低。方法和结果：30名年龄> 60岁，11名健康，9名HFNEF，10名HFREF的参与者接受了股浅表动脉FMAD的心血管磁共振（CMR）评估，随后在48小时内进行了症状受限的运动过期气体分析。老年HFREF和HFNEF患者的峰值耗氧量（Vo（2峰值）;分别为12 +/- 2和13 +/- 1 ml.kg（-1）.min（-1））年龄匹配的当代人（20 +/- 3 ml.kg（-1）.min（-1））。 HFREF患者的FMAD为3.8 +/- 1.3％（0.85 +/- 0.22 mm（2））;在HFNEF和年龄相匹配的健康老年人中，分别为12.1 +/- 3.6％（3.1 +/- 1.2 mm（2））和13.7 +/- 5.9％（3.9 +/- 1.7 mm（2））个人。调整年龄和性别后，健康和HFREF受试者的FMAD与Vo（2）的关联性较高（分别为P = 0.05和0.02），而HFNEF受试者的关联性则较低（P = 0.58）。结论：老年HFNEF患者的腿部FMAD没有明显减少。这些数据表明，除了股动脉内皮功能受损外，其他机制还导致这些人严重的运动不耐症。

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