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首页> 外文期刊>American Journal of Physiology >Temporal and spatial variations of cell-free layer width in arterioles.
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Temporal and spatial variations of cell-free layer width in arterioles.

机译：小动脉中无细胞层宽度的时空变化。

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摘要

Separation of red blood cells and plasma in microcirculatory vessels produces a cell-free layer at the wall. This layer may be an important determinant of blood viscosity and wall shear stress in arterioles, where most of the hydraulic pressure loss in the circulatory system occurs and flow regulatory mechanisms are prominent. With the use of a newly developed method, the width of the cell-free layer was rapidly and repeatedly determined in arterioles (10- to 50-microm inner diameter) in the rat cremaster muscle at normal arterial pressure. The temporal variation of the cell-free layer width was non-Gaussian, but calculated mean and median values differed by <0.2 microm. The correlation length of the temporal variations downstream (an indication of mixing) was approximately 30 microm and was independent of pseudoshear rate (ratio of mean velocity to vessel diameter) and of vessel diameter. The cell-free layer width was significantly different on opposite sides of the vessel and inversely related. Increasing red blood cell aggregability reduced this inverse relation but had no effect on correlation length. In the diameter range studied, the mean width of the cell-free layer increased from 0.8 to 3.1 microm and temporal variations increased from 30% to 70% of the mean width. Increased aggregability did not alter either relationship. In summary, the cell-free layer width in arterioles is diameter dependent and shows substantial non-Gaussian temporal variations. The temporal variations increase as diameter increases and are inversely related on opposite sides of the vessel.
机译：微循环血管中红细胞和血浆的分离在壁上产生了无细胞层。该层可能是决定小动脉血液粘度和壁切应力的重要决定因素，其中循环系统中的大部分液压损失都会发生，并且流量调节机制很重要。通过使用新开发的方法，在正常动脉压下，大鼠提睾肌中的小动脉（内径为10至50微米）中的无细胞层的宽度可以快速重复地确定。无细胞层宽度的时间变化是非高斯的，但计算的平均值和中值相差<0.2微米。下游时间变化的相关长度（混合指示）约为30微米，并且与假剪切率（平均速度与血管直径的比率）和血管直径无关。无细胞层宽度在容器的相对侧上显着不同并且成反比。红细胞凝集力的增加减少了这种反比关系，但对相关长度没有影响。在研究的直径范围内，无孔层的平均宽度从0.8微米增加到3.1微米，时间变化从平均宽度的30％增加到70％。聚集性的提高并未改变任何一种关系。总之，小动脉中无细胞层的宽度取决于直径，并显示出很大的非高斯时间变化。时间变化随着直径的增加而增加，并且在血管的相对侧成反比。

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