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首页> 外文期刊>American Journal of Physiology >Peculiar flow patterns of RBCs suspended in viscous fluids and perfused through a narrow tube (25 microm).
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Peculiar flow patterns of RBCs suspended in viscous fluids and perfused through a narrow tube (25 microm).

机译：悬浮在粘性流体中并通过细管（25微米）灌注的RBC的特殊流动模式。

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摘要

Red blood cells (RBCs) generally deform to adopt a parachute-like, torpedo-like, or other configuration to align and flow through a capillary that is narrower than their major axis. As described herein, even in a narrow tube (25 microm) with diameter much larger than that of a capillary, flowing RBCs at 1 mm/s align axially and deform to a paraboloid shape in a viscous Newtonian fluid (505 kDa dextran medium) with viscosity of 23.4-57.1 mPa.s. A high-speed digital camera image showed that the silhouette of the tip of RBCs fits a parabola, unlike the shape of RBCs in capillaries, because of the longer distance of the RBC-free layer between the tube wall and the RBC surface ( approximately 8.8 microm). However, when RBCs are suspended in a "non-Newtonian" viscous fluid (liposome-40 kDa dextran medium) with a shear-thinning profile, they migrate toward the tube wall to avoid the axial lining, as "near-wall-excess," which is usually observed for platelets. This migration results from the presence of flocculated liposomes at the tube center. In contrast, such near-wall excess was not observed when RBCs were suspended in a nearly Newtonian liposome-albumin medium. Such unusual flow patterns of RBCs would be explainable by the principle; a larger particle tends to flow near the centerline, and a small one tends to go to the wall to flow with least resistance. However, we visualized for the first time the complete axial aligning and near-wall excess of RBCs in the noncapillary size tube in some extreme conditions.
机译：红细胞（RBC）通常会变形以采用降落伞状，鱼雷状或其他构造，以排列并流过比其主轴窄的毛细管。如此处所述，即使在直径比毛细管大得多的细管（25微米）中，在粘性牛顿流体（505 kDa葡聚糖介质）中，以1 mm / s流动的RBC也会轴向排列并变形为抛物面形状。粘度为23.4-57.1mPa.s。高速数码相机图像显示，与毛细管中的RBC形状不同，RBC尖端的轮廓适合抛物线，这是因为管壁和RBC表面之间的无RBC层的距离较长（大约8.8微米）。但是，当RBC悬浮在具有剪切变稀特性的“非牛顿”粘性流体（脂质体40 kDa葡聚糖介质）中时，它们会朝着管壁迁移以避免轴向衬里，如“近壁过多，通常在血小板中观察到。这种迁移是由于在管中心存在絮凝的脂质体引起的。相反，当将红细胞悬浮在近牛顿脂质体-白蛋白培养基中时，未观察到这种近壁过量。原理可以解释红细胞的这种异常流动模式;较大的粒子倾向于在中心线附近流动，而较小的粒子倾向于以最小的阻力流到壁上。但是，我们首次在某些极端条件下可视化了非毛细管尺寸管中RBC的完全轴向对准和近壁过量。

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