STAT6 regulates natural helper cell proliferation during lung inflammation initiated by Alternaria

Taylor A. Doherty; Naseem Khorram; Jinny E. Chang; Hee-Kyoo Kim; Peter Rosenthal

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STAT6 regulates natural helper cell proliferation during lung inflammation initiated by Alternaria

机译：STAT6在交链孢菌引发的肺部炎症过程中调节自然辅助细胞的增殖

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Our previous studies demonstrated that Alternaria can induce an innate eosinophilia in the airway compared with other allergens that is dependent on STAT6 (7). The finding that different aeroallergens may induce unique innate responses is supported by a report that the house dust mite (HDM) Der-matophagoides pteronyssinus contains an accessory protein homolog of MD-2 that can specifically activate Toll-like receptor type 4 signaling (39). Aside from this, mechanisms whereby individual allergens can specifically activate the innate immune system are largely unknown.

机译：我们以前的研究表明，与依赖STAT6的其他过敏原相比，链格孢菌可以在气道中诱发先天性嗜酸性粒细胞增多（7）。一份关于室内尘螨（Der-matophagoides pteronyssinus）含有MD-2的辅助蛋白同源物的报道支持不同的空气变应原可能诱导独特的先天反应这一发现（39）。除此以外，各个变应原可以特异性激活先天免疫系统的机制尚不清楚。

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《American Journal of Physiology》 |2012年第1期|共12页
作者
Taylor A. Doherty; Naseem Khorram; Jinny E. Chang; Hee-Kyoo Kim; Peter Rosenthal;
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1. STAT6 regulates natural helper cell proliferation during lung inflammation initiated by Alternaria [J] . Taylor A. Doherty, Naseem Khorram, Jinny E. Chang, American Journal of Physiology . 2012,第4aPta1期

机译：STAT6在交链孢菌引发的肺部炎症过程中调节自然辅助细胞的增殖
2. STAT6 Controls the Number of Regulatory T Cells In Vivo, Thereby Regulating Allergic Lung Inflammation [J] . Nicolas J. Dorsey, Svetlana P. Chapoval, Elizabeth P. Smith, The journal of immunology . 2013,第4期

机译：STAT6控制体内调节性T细胞的数量，从而调节过敏性肺炎
3. STAT6 controls the number of regulatory T cells in vivo, thereby regulating allergic lung inflammation [J] . DorseyN.J., ChapovalS.P., SmithE.P., The Journal of Immunology: Official Journal of the American Association of Immunologists . 2013,第4期

机译：STAT6控制体内调节性T细胞的数量，从而调节过敏性肺部炎症
4. Over-activation of the stat3 pathway in lung epithelial cells induces pulmonary inflammation and lung cancer [C] . Liu Yujie, rnPiao Linhua, rnSong Jia, Journal of Organ Dysfunction: ISRD 2007 Abstract Book . 2007

机译：肺上皮细胞中stat3通路的过度激活引起肺部炎症和肺癌
5. The role of STAT6 modulation of natural and inducible Tregs during Allergic Lung Inflammation. [D] . Dorsey, Nicolas. 2013

机译：STAT6调节天然和诱导性Treg在变应性肺炎症中的作用。
6. STAT6 regulates natural helper cell proliferation during lung inflammation initiated by Alternaria [O] . Taylor A. Doherty, Naseem Khorram, Jinny E. Chang, -1

机译：STAT6调节链格孢菌引发的肺部炎症期间的自然辅助细胞增殖
7. STAT6 Controls the Number of Regulatory T Cells In Vivo, Thereby Regulating Allergic Lung Inflammation [O] . Nicolas J. Dorsey, Svetlana P. Chapoval, Elizabeth P. Smith, 2013

机译：Stat6控制体内调节T细胞的数量，从而调节过敏性肺炎症

STAT6 regulates natural helper cell proliferation during lung inflammation initiated by Alternaria

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