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首页> 外文期刊>Analytical chemistry >Fully Automatic Sample Treatment by Integration of Microextraction by Packed Sorbents into Commercial Capillary Electrophoresis-Mass Spectrometry Equipment: Application to the Determination of Fluoroquinolones in Urine
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Fully Automatic Sample Treatment by Integration of Microextraction by Packed Sorbents into Commercial Capillary Electrophoresis-Mass Spectrometry Equipment: Application to the Determination of Fluoroquinolones in Urine

机译：通过将吸附剂微萃取集成到商用毛细管电泳-质谱仪中的全自动样品处理：在尿液中氟喹诺酮类药物的测定中的应用

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摘要

This paper describes a new and innovative way to integrate microextraction by packed sorbents (MEPS) into commercial CE equipment. The suggested integration allows the automatic sample cleanup and preconcentration requiring only a few microliters of sample and no additional hardware and software. The MEPS was integrated in the outlet region of a commercial CE equipment cartridge in order to provide easy manipulation and exchange. The robustness of the proposed integration was demonstrated by the design and use of a (MEPS)-nonaqueous capillary electrophoresis (NACE)-MS method used to determine fluoroquinolones "FQs" (namely, ofloxacin, marbofloxacin, enrofloxacin, danofloxacin, and difloxacin) in urine. The method allows the analysis of micrograms per liter of FQs to be carried out with only 48 (mu)L of urine sample. The obtained LODs were in the range 6.3-10.6 (mu)g/L. An analysis of spiked urine samples was used to validate the method. Absolute recoveries were in the range of 71-109percent while the precision expressed as repetitivity of peak area was lower than 5.9percent.
机译：本文介绍了一种新的创新方法，可将填充吸附剂（MEPS）的微萃取技术集成到商用CE设备中。建议的集成可实现自动样品清洁和预浓缩，仅需几微升样品，而无需其他硬件和软件。 MEPS集成在商用CE设备墨盒的出口区域中，以便于操作和更换。通过设计和使用（MEPS）-非水毛细管电泳（NACE）-MS方法确定氟喹诺酮类“ FQ”（即氧氟沙星，马尔波沙星，恩诺沙星，达诺沙星和地氟沙星），证明了所提出的积分方法的鲁棒性。尿。该方法允许仅用48μL尿液样品对每升FQ进行​​微克分析。所获得的LOD在6.3-10.6μg/ L的范围内。对加标尿液样品的分析用于验证该方法。绝对回收率在71-109％的范围内，而以峰面积的重复性表示的精度低于5.9％。

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